Primary ovarian insufficiency occurs when the ovaries stop functioning as they should before age 40. When this happens, your ovaries don't produce typical amounts of the hormone estrogen or release eggs regularly. This condition is also called premature ovarian failure and often leads to infertility.
Primary ovarian insufficiency is sometimes confused with premature menopause, but these conditions aren't the same. Women with primary ovarian insufficiency can have irregular or occasional periods for years and might even get pregnant. But women with premature menopause stop having periods and can't become pregnant.
Restoring estrogen levels in women with primary ovarian insufficiency helps prevent some complications that occur as a result of low estrogen, such as osteoporosis.
Signs and symptoms of primary ovarian insufficiency are similar to those of menopause or estrogen deficiency. They include:
- Irregular or skipped periods, which might be present for years or develop after a pregnancy or after stopping birth control pills
- Difficulty getting pregnant
- Hot flashes
- Night sweats
- Vaginal dryness
- Dry eyes
- Irritability or difficulty concentrating
- Decreased sexual desire
When to see a health care provider
If you've missed your period for three months or more, see your health care provider to determine the cause. You can miss your period for a number of reasons — including pregnancy, stress, or a change in diet or exercise habits — but it's best to get evaluated whenever your menstrual cycle changes.
Even if you don't mind not having periods, it's advisable to see your provider to find out what's causing the change. Low estrogen levels can lead to bone loss and an increased risk of heart disease.
Primary ovarian insufficiency may be caused by:
- Chromosome changes. Some genetic disorders are associated with primary ovarian insufficiency. These include conditions in which you have one typical X chromosome and one altered X chromosome (mosaic Turner syndrome) and in which X chromosomes are fragile and break (fragile X syndrome).
- Toxins. Chemotherapy and radiation therapy are common causes of toxin-induced ovarian failure. These therapies can damage genetic material in cells. Other toxins such as cigarette smoke, chemicals, pesticides and viruses might hasten ovarian failure.
- An immune system response to ovarian tissue (autoimmune disease). In this rare form, your immune system produces antibodies against your ovarian tissue, harming the egg-containing follicles and damaging the egg. What triggers the immune response is unclear, but exposure to a virus is one possibility.
- Unknown factors. The cause of primary ovarian insufficiency is often unknown (idiopathic). Your health care provider might recommend further testing to find the cause, but in many cases, the cause remains unclear.
Factors that increase your risk of developing primary ovarian insufficiency include:
- Age. The risk goes up between ages 35 and 40. Although rare before age 30, primary ovarian insufficiency is possible in younger women and even in teens.
- Family history. Having a family history of primary ovarian insufficiency increases your risk of developing this disorder.
- Ovarian surgery. Surgeries involving the ovaries increase the risk of primary ovarian insufficiency.
Complications of primary ovarian insufficiency include:
- Infertility. Inability to get pregnant can be a complication of primary ovarian insufficiency. In rare cases, pregnancy is possible until the eggs are depleted.
- Osteoporosis. The hormone estrogen helps maintain strong bones. Women with low levels of estrogen have an increased risk of developing weak and brittle bones (osteoporosis), which are more likely to break than healthy bones.
- Depression or anxiety. The risk of infertility and other complications arising from low estrogen levels causes some women to become depressed or anxious.
- Heart disease. Early loss of estrogen might increase your risk.