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<?xml version="1.0" encoding="UTF-8" standalone="no"?><merged xmlns:dita-ot="http://dita-ot.sourceforge.net/ns/201007/dita-ot" id="GUID-989bebdc-63bd-4d21-a9a1-cb5671b47a91-en" xml:lang="en" xtrf="file:/mnt/crx/author/crx-quickstart/profiles/ditamaps/ditamap14164923435549045716/hecs-ccms/en/HIL/conditions/p-r/polymyositis/polymyositis.ditamap"> <displayTitle>Polymyositis</displayTitle> <featureTitle/> <listTitle/> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/Overview" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:MDWvvDZzwFTS5ura6JuMFS:2026-10-09" xml:lang="en"> <title>overview polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-overview">Overview</titleSimple> </titlealts> <conbody> <p product="mayoclinic.org"> <xref href="https://www.mayoclinic.org/about-this-site/meet-our-medical-editors" keyref="attrib-mayo-clinic-staff-link" scope="external">By Mayo Clinic Staff</xref> </p> <conbodydiv platform="richtext"> <section> <p>Polymyositis (pol-e-my-o-SY-tis) is a condition in which swelling and irritation, called inflammation, happens when the immune system attacks its own muscle tissues. Polymyositis causes weakness of the muscles involved in body movement, called skeletal muscles. Muscle weakness most often happens on both sides of the body at the same time.</p> <p>The condition, also called an autoimmune condition, isn't common. Having this condition can make it hard to climb stairs, rise from sitting, lift objects or reach up.</p> <p>Polymyositis most often affects adults in their 40s to 60s. Symptoms tend to come on slowly, over weeks or months.</p> <p>There's no cure for polymyositis. But treatment can improve muscle strength and help muscles work better. Treatments include medicines and physical therapy.</p> </section> </conbodydiv> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/Symptoms" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:466sqjEd23VbrWvadd4WnQ:2026-10-09" xml:lang="en"> <title>symptoms polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-symptoms">Symptoms</titleSimple> </titlealts> <conbody> <conbodydiv platform="richtext"> <section> <p>The muscle weakness of polymyositis most often involves the muscles closest to the central part of the body, called the trunk. It may affect the muscles of the hips, shoulders and neck. Muscles on both sides of the body weaken. In polymyositis, muscle weakness tends to get worse slowly.</p> </section> </conbodydiv> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/WhenToSeekCare" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:NFoTupCxSZLVg7NRDrfGwi:2026-10-09" xml:lang="en"> <title>When to see a doctor polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-when-to-see-doctor">When to see a doctor</titleSimple> </titlealts> <conbody> <p>Make an appointment with a healthcare professional if you get muscle weakness.</p> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/Causes" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:9yykEqyEc5jG8KvLk3ALQX:2026-10-09" xml:lang="en"> <title>causes polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-causes">Causes</titleSimple> </titlealts> <conbody> <conbodydiv platform="richtext"> <section> <p>Experts don't know the exact cause of polymyositis. Having certain gene changes may make people more likely to get the condition.</p> </section> </conbodydiv> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/RiskFactors" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:13G96tzg7MG8bLPdujAL8X:2026-10-09" xml:lang="en"> <title>risk factors polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-risk-factors">Risk factors</titleSimple> </titlealts> <conbody> <conbodydiv platform="richtext"> <section> <p>People assigned female at birth have a higher risk of polymyositis than do people assigned male at birth.</p> </section> </conbodydiv> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/Complications" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:BR9CdCacPfFzmL9wtQeQPb:2026-10-09" xml:lang="en"> <title>complications polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-complications">Complications</titleSimple> </titlealts> <conbody> <conbodydiv platform="richtext"> <section> <p>Complications of polymyositis may include:</p> <ul> <li> <b>Trouble swallowing.</b> The condition may affect the muscles in the tube that carries food from the throat to the stomach, called the esophagus. This can lead to trouble swallowing, called dysphagia. Trouble swallowing may cause weight loss and not getting enough nutrition.</li> <li> <b>Aspiration pneumonia.</b> Trouble swallowing may also cause the breathing of food or liquids, including saliva, into the lungs. This is called aspiration and can lead to pneumonia.</li> <li> <b>Breathing problems.</b> Polymyositis may affect the chest muscles. This can cause trouble breathing, such as shortness of breath. If breathing is affected enough, it can cause failure of the system that allows breathing, called respiratory failure.</li> </ul> </section> <section> <title>Linked conditions</title> <p>Polymyositis is often linked with other conditions that may cause more complications. Conditions include:</p> <ul> <li> <b>Raynaud's disease.</b> This condition causes the fingers, toes, cheeks, nose and ears to turn white, purple or red in response to cold temperatures or stress. Color changes may be harder to see on Black or brown skin. The condition also may cause numbness and tingling.</li> <li> <b>Other diseases.</b> Other autoimmune conditions, such as lupus, rheumatoid arthritis, scleroderma and Sjogren syndrome, can happen with polymyositis.</li> <li> <b>Cardiovascular disease.</b> Polymyositis may cause the muscular walls of the heart to become inflamed, called myocarditis. A small number of people who have polymyositis may get congestive heart failure and irregular heart rhythms called arrythmias.</li> <li> <b>Lung disease.</b> A condition called interstitial lung disease may happen with polymyositis. Interstitial lung disease is a group of conditions that cause scarring of lung tissue. Called fibrosis, the scarring makes lung tissue stiff and thick. This makes it hard for the lungs to expand and fill with air.</li> <li> <b>Cancer.</b> People who have polymyositis may have a higher a risk of cancer.</li> </ul> </section> </conbodydiv> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/Diagnosis" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:WzpPXGgr9SXzz6BtewpZhH:2026-10-09" xml:lang="en"> <title>diagnosis polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-diagnosis">Diagnosis</titleSimple> </titlealts> <conbody> <conbodydiv platform="richtext"> <section> <p>To diagnose polymyositis, a healthcare professional does a physical exam and checks muscle strength. The following tests may help with diagnosis:</p> <ul> <li> <b>Blood tests.</b> A blood test may show higher levels of muscle enzymes, which can mean muscle damage. A blood test also can detect immune cells called autoantibodies linked with certain symptoms of polymyositis.</li> <li> <b>Electromyography.</b> For this test, a healthcare professional puts a thin needle electrode through the skin and into the muscle. The test measures electrical activity of the muscles as they relax or tighten. Changes in the pattern of electrical activity can confirm a muscle disease. Testing different muscles can show which ones the condition affects.</li> <li> <b>MRI.</b> A magnetic field and radio waves from a computer make detailed pictures of the muscles. An MRI can find swelling and irritation, called inflammation, over a large area of affected muscle.</li> <li> <b>Muscle biopsy.</b> A healthcare professional removes a small piece of muscle tissue to send to a lab for study. The results can show muscle damage and swelling and irritation, called inflammation. A biopsy may be needed to diagnose polymyositis.</li> <li> <b>Lung tests.</b> Your healthcare professional may suggest tests to see how well the lungs work and a CT of the chest. You may have these tests if you have certain autoantibodies that have been linked with a condition of lung scarring called interstitial lung disease that may happen with dermatomyositis.</li> </ul> </section> </conbodydiv> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/Treatment" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:CWUqwyCshJkDvkjdZR4ifn:2026-10-09" xml:lang="en"> <title>treatment polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-treatment">Treatment</titleSimple> </titlealts> <conbody> <conbodydiv platform="richtext"> <section> <p>There's no cure for polymyositis. But treatment can improve muscle strength and help muscles work better. Your healthcare professional bases your treatment on your symptoms and how well the treatment manages them.</p> </section> <section> <title>Medications</title> <p>The most common medicines to treat polymyositis include:</p> <ul> <li> <b>Corticosteroids.</b> Medicines such as prednisone can manage polymyositis symptoms well. But using these medicines over time can cause serious side effects, including muscle weakness. So your healthcare professional tapers the dosage little by little.</li> <li> <b>Corticosteroid-sparing agents.</b> When used with a corticosteroid, these medicines may allow for a lower dosage of the corticosteroid and fewer side effects. The two most common medicines for polymyositis are azathioprine (Azasan, Imuran) and methotrexate (Trexall, Xatmep).</li> <li> <b>Medicines for more-serious illness.</b> Other medicines for polymyositis include mycophenolate mofetil (CellCept, Myhibbin), cyclosporine (Gengraf, Neoral, others), tacrolimus (Astagraf XL, Prograf, others) and rituximab (Rituxan). These medicines can lessen the need for long-term corticosteroids.</li> <li> <p> <b>Intravenous immunoglobulin.</b> Also called IVIg, this purified blood product has healthy antibodies from thousands of blood donors. These healthy antibodies can block the antibodies that attack muscle in polymyositis.</p> <p>Treatment with IVIg involves getting the medicine through a vein, called an infusion. IVIg treatments may be used regularly or sometimes. The treatment mainly helps with trouble swallowing.</p> </li> </ul> </section> <section> <title>Therapy</title> <p>Depending on the how serious the symptoms are, treatment might include:</p> <ul> <li> <b>Physical therapy.</b> A physical therapist can show you exercises to improve your strength and tell you what level of activity is right for you.</li> <li> <b>Speech therapy.</b> If polymyositis weakens muscles used for swallowing, speech therapy can help you learn how to work with the weakness.</li> <li> <b>Nutrition help.</b> Over time, polymyositis can make it harder to chew and swallow. A registered dietitian can teach you how to make easy-to-eat foods that give you enough nutrition.</li> </ul> </section> </conbodydiv> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/CopingAndSupport" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:GrNVXZyNKbUZvWHkrJ1dKB:2026-10-09" xml:lang="en"> <title>coping and support polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-coping-and-support">Coping and support</titleSimple> </titlealts> <conbody> <conbodydiv platform="richtext"> <section> <p>Living with a chronic condition can be a challenge. To help you cope, try adding the following suggestions to your medical care:</p> <ul> <li> <b>Know your illness.</b> Read all you can about polymyositis and other muscle conditions. Talk with people who have conditions like yours. Ask your healthcare professional any questions that you have about your condition, diagnosis or treatment.</li> <li> <b>Be a part of your medical team.</b> Work with the healthcare professionals involved in your care. Follow your treatment plan, including physical therapy. Tell your healthcare team about any new symptoms you have.</li> <li> <b>Know your limits.</b> Ask for help when you need it. And let others know about the ways polymyositis limits you.</li> <li> <b>Rest when you're tired.</b> Don't wait until you're worn out. Learn to pace yourself so that you keep up your energy level, get done what you need to do and feel better mentally.</li> <li> <p> <b>Accept your feelings.</b> Dealing with an ongoing illness may cause anger, sadness and other feelings. You might feel like your life is out of control and that you're alone.</p> <p>Stay close to family and friends. Stick to your daily routine as best you can. Do things you enjoy. Many people find support groups helpful.</p> </li> </ul> </section> </conbodydiv> </conbody> </hecsConcept> <hecsConcept contentType="http://ontology.mayo.edu/ContentCategories/AppointmentPreparation" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:JM8zuMFBCVGZRCzumyB7iu:2026-10-09" xml:lang="en"> <title>preparing for your appointment polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-prep-for-appt">Preparing for your appointment</titleSimple> </titlealts> <conbody> <conbodydiv platform="richtext"> <section> <p>Start by seeing your main healthcare professional, who might send you to a specialist in conditions of the joints, muscles and bone, called a rheumatologist. Or you might see a specialist in conditions of the nervous system, called a neurologist.</p> </section> <section> <title>What you can do</title> <p>Make a list of:</p> <ul> <li> <b>Your symptoms,</b> including when they began and which muscles are affected.</li> <li> <b>Key personal information,</b> including major stresses, recent life changes, and your and your family's medical history.</li> <li> <b>All medicines, vitamins and other supplements</b> you take, including the dosages.</li> <li> <b>Questions to ask</b> your healthcare professional.</li> </ul> <p>For polymyositis, some questions to ask include:</p> <ul> <li>What is the likely cause of my symptoms?</li> <li>What are other possible causes for my symptoms?</li> <li>What tests do I need? Do I need to do anything to prepare for them?</li> <li>What treatments do you suggest?</li> <li>I have other medical conditions. How can I best manage them together?</li> <li>Do you have brochures or other printed material that I can have? What websites do you suggest?</li> </ul> <p>Be sure to ask all the questions you have.</p> </section> <section> <title>What to expect from your doctor</title> <p>Your healthcare professional may ask you questions, such as:</p> <ul> <li>Did your symptoms come on slowly or did they start all at once?</li> <li>Do you easily tire during waking hours?</li> <li>What does your condition keep you from doing?</li> <li>Has anyone in your family been diagnosed with a condition that affects the muscles?</li> <li>What, if anything, seems to make your symptoms better?</li> <li>What, if anything, seems to make your symptoms worse?</li> </ul> </section> </conbodydiv> </conbody> </hecsConcept> <hecsReference contentType="http://ontology.mayo.edu/ContentCategories/References" policy="did:mcid:PDkv3FCzsA4FPiHVvT1zRc;did:mcid:7AmKpSty59qW9PRkXPDxNB" reviewedOn="2022-08-10T05:00:00.000-05:00" workId="did:mcid:QmFKfWbnqrR2J3o1Au5Fhc:2026-10-09" xml:lang="en"> <title>references polymyositis</title> <titlealts> <titleSimple keyref="titleSimple-references">References</titleSimple> </titlealts> <prolog> <footnotes> <fn>Inflammatory myopathies. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/health-information/disorders/inflammatory-myopathies?search-term=polymyositis#. Accessed Jan. 30, 2025.</fn> <fn>Inflammatory myopathies. American College of Rheumatology. https://rheumatology.org/patients/inflammatory-myopathies. Accessed Jan. 30, 2025.</fn> <fn>Idiopathic inflammatory myopathies. Merck Manual Professional Version. https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/systemic-rheumatic-diseases/idiopathic-inflammatory-myopathies. Accessed Jan. 30, 2025.</fn> <fn>Christopher-Stine L, et al. Clinical manifestations of dermatomyositis and polymyositis in adults. https://www.uptodate.com/contents/search. Accessed Jan. 30, 2025.</fn> <fn>Christopher-Stine L. Initial treatment of dermatomyositis and polymyositis in adults. https://www.uptodate.com/contents/search. Accessed Jan. 30, 2025.</fn> <fn>Johnson, S.R., et al. 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the screening and monitoring of interstitial lung disease in people with systemic autoimmune rheumatic diseases. 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