Peripheral nerve tumors

By Mayo Clinic Staff
July 19, 2024

Research

Mayo Clinic researchers have a long tradition of studying new ways of diagnosing and treating peripheral nerve disorders, including tumors.

Researchers from many areas work to improve diagnosis and treatment for people with peripheral nerve disorders and peripheral nerve tumors. Those areas include neurology, neurosurgery, medical genetics, laboratory medicine and pathology, along with other areas.

These researchers have:

  • Identified a new syndrome.
  • Identified specific gene changes implicated in a type of peripheral nerve tumor.
  • Identified the mechanism for and treatment of intraneural ganglion cysts.
  • Proved that cancers can spread along peripheral nerves.
  • Proved that noninvasive imaging techniques such as PET-MRI can distinguish a benign tumor from a cancerous one. This means that malignancies can be identified without the need for surgery.

Read more about nerve tumor research at Mayo Clinic.

Peripheral nerve tumor researchers

Mayo Clinic researchers discuss peripheral nerve tumors.

Laboratories

Scientists in the following Mayo Clinic laboratories are active in peripheral nerve tumor research:

Publications

See a list of publications about peripheral nerve tumors by Mayo Clinic on PubMed, a service of the National Library of Medicine.

  1. Jankovic J, et al., eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Oct. 12, 2022.
  2. Brunicardi FC, et al, eds. Neurosurgery. In: Schwartz's Principles of Surgery. 11th ed. McGraw Hill; 2019. https://accessmedicine.mhmedical.com. Accessed Oct. 12, 2022.
  3. Quinones-Hinojosa A, et al., eds. Peripheral nerve tumors of the extremities. In: Schmidek & Sweet: Operative Neurosurgical Techniques. 7th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Oct. 12, 2022.
  4. Ge L-L, et al. Neurofibroma development in neurofibromatosis type 1: Insights from cellular origin and Schwann cell lineage development. Cancers. 2022; doi:10.3390/cancers14184513.
  5. Goldblum JR, et al. Benign tumors of peripheral nerves. In: Enzinger and Weiss's Soft Tissue Tumors. 7th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed October 12, 2022.
  6. Abdel Razek AAK, et al. Peripheral nerve sheath tumors of head and neck: Imaging-based review of World Health Organization classification. Journal of Computer Assisted Tomography. 2020; doi:10.1097/RCT.0000000000001109.
  7. Malignant peripheral nerve sheath tumor. Genetic and Rare Diseases Information Center. https://rarediseases.info.nih.gov/diseases/10872/malignant-peripheral-nerve-sheath-tumor/living. Accessed Oct. 14, 2022.
  8. Babovic-Vuksanovic D, et al. Multiple orbital neurofibromas, painful peripheral nerve tumors, distinctive face and marfanoid habitus: A new syndrome. European Journal of Human Genetics. 2012; doi:10.1038/ejhg.2011.275.
  9. Klein CJ, et al. Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas. Annals of Neurology. 2017; doi:10.1002/ana.24854.
  10. Spinner RJ, et al. The unifying articular (synovial) origin for intraneural ganglion cysts: Moving beyond a theory. Journal of Hand Surgery. 2016; doi:10.1016/j.jhsa.2016.04.004.
  11. Capek S, et al. Perineural spread of pelvic malignancies to the lumbosacral plexus and beyond: Clinical and imaging patterns. Neurosurgical Focus. 2015; doi:10.3171/2015.7.FOCUS15209.
  12. Broski SM, et al. Evaluation of (18)F-FDG PET and MRI in differentiating benign and malignant peripheral nerve sheath tumors. Skeletal Radiology. 2016; doi:10.1007/s00256-016-2394-7.
  13. Stucky C-CH, et al. Malignant peripheral nerve sheath tumors (MPNST): The Mayo Clinic experience. 2012; doi:10.1245/s10434-011-1978-7.
  14. Wise SC, et al. Surgical salvage of recurrent vestibular schwannoma following prior stereotactic radiosurgery. Laryngoscope. 2016; doi:10.1002/lary.25943.
  15. Find a cancer center. National Cancer Institute. https://www.cancer.gov/research/infrastructure/cancer-centers/find. Accessed Oct. 14, 2022.
  16. Desy NM, et al. Intraneural ganglion cysts: A systematic review and reinterpretation of the world's literature. Journal of Neurosurgery. 2016: doi:10.3171/2015.9.JNS141368.
  17. Ami TR. Allscripts EPSi. Mayo Clinic. May 13, 2022.