Perimenopause

By Mayo Clinic Staff
Aug. 22, 2026

Research

Mayo Clinic's experts continue to innovate in the diagnosis and treatment of obstetric and gynecologic conditions, including care during perimenopause. The mission of Mayo Clinic's Women's Health Research Center is to advance scientific discoveries to improve the health of women through all life stages.

The center supports projects focused on how unique processes of the female body, such as pregnancy and menopause, impact health factors such as cardiovascular disease, blood pressure, pain response and more.

See a list of publications about perimenopause and menopause by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Lobo RA, et al. Menopause and care of the mature woman: Endocrinology, consequences of estrogen deficiency, effects of hormone therapy, and other treatment options. In: Comprehensive Gynecology. 8th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Feb. 27, 2025.
  2. AskMayoExpert. Menopausal hormone therapy. Mayo Clinic; 2023.
  3. AskMayoExpert. Bioidentical hormones. Mayo Clinic; 2023.
  4. DHEA. NatMed. https://naturalmedicines.therapeuticresearch.com/. Accessed March 14, 2025.
  5. Black cohosh. NatMed. https://naturalmedicines.therapeuticresearch.com/. Accessed Feb. 27, 2025.
  6. Ferri FF. Menopause. In: Ferri's Clinical Advisor 2025. Elsevier; 2025. https://www.clinicalkey.com. Accessed Feb. 27, 2025.
  7. Menopausal symptoms: In depth. National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/menopausal-symptoms-in-depth. Accessed March Feb. 27, 2025.
  8. Menopause. Merck Manual Professional Version. https://www.merckmanuals.com/professional/gynecology-and-obstetrics/menopause/menopause. Accessed Feb. 27, 2025.
  9. Casper RF, eds. Clinical manifestations and diagnosis of menopause. https://www.uptodate.com/contents/search. Accessed Feb. 27, 2025.
  10. FAQs: The menopause years. American College of Obstetricians and Gynecologists. https://www.acog.org/womens-health/faqs/the-menopause-years. Accessed Feb. 27, 2025.
  11. Nimmagadda R. Allscripts EPSi. Mayo Clinic. Jan. 16, 2025.
  12. Smith-Francis MJ. Complementary and alternative medicine for menopause. Nursing Clinics of North America. 2024; doi:10.1016/j.cnur.2024.08.001.
  13. American College of Obstetricians and Gynecologists. Practice Bulletin No. 128: Diagnosis of abnormal uterine bleeding in reproductive-aged women. Obstetrics and Gynecology. 2012; doi:10.1097/AOG.0b013e318262e320. Reaffirmed 2024.
  14. American College of Obstetricians and Gynecologists. Practice Bulletin No. 141: Management of menopausal symptoms. Obstetrics & Gynecology. 2014; doi:10.1097/01.AOG.0000441353.20693.78. Reaffirmed 2024.
  15. Canivenc-Lavier, et al. Phytoestrogens and health effects. Nutrients. 2023; doi:10.3390/nu15020317.
  16. FDA approves novel drug to treat moderate to severe hot flashes caused by menopause. U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-approves-novel-drug-treat-moderate-severe-hot-flashes-caused-menopause. Accessed March 20, 2025.
  17. Veozah (prescribing information). Astellas Pharma US, Inc.; 2024 https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/216578s000lbl.pdf. Accessed Feb. 27, 2025.
  18. Menopause basics. Office on Women's Health. https://www.womenshealth.gov/menopause-basics. Accessed March 11, 2025.
  19. Menopause treatment. Office on Women's Health. https://www.womenshealth.gov/menopause-treatment. Accessed March 20, 2025.
  20. Menopause and sexuality. Office on Women's Health. https://www.womenshealth.gov/menopause-and-sexuality. Accessed March 20, 2025.
  21. Menopause symptoms and relief. Office on Women's Health. https://www.womenshealth.gov/menopause-symptoms-and-relief. Accessed March 20, 2025.
  22. Early or premature menopause. Office on Women's Health. https://www.womenshealth.gov/early-or-premature-menopause. Accessed March 22, 2025.
  23. Medical review (expert opinion). Mayo Clinic. March 30, 2025.
  24. Nonhormone treatments for hot flashes and night sweats. The Menopause Society. https://menopause.org/wp-content/uploads/default-document-library/nonhormone-treatment-menonote_f5afc19f-211e-4c1f-8a04-b2d558c6fa66.pdf. https://menopause.org/patient-education/menonotes. Accessed March 31, 2025.
  25. Bioidentical hormone therapy: Custom compounded versus government approved. The Menopause Society. https://menopause.org/patient-education/menonotes. Accessed March 31, 2025.
  26. AskMayoExpert. Genitourinary syndrome of menopause. Mayo Clinic; 2024.
  27. AskMayoExpert. Hot flashes. Mayo Clinic; 2026.