Parkinson's disease

By Mayo Clinic Staff
Sept. 27, 2024

Research

Mayo Clinic doctors trained in nervous system conditions (neurologists) and other specialties conduct extensive research in genetics, causes, new diagnostic tests and treatments for Parkinson's disease and other movement disorders. For example, Mayo researchers have found that testing a person's saliva gland may be helpful in confirming a diagnosis of Parkinson's disease, and as a tool for researchers to understand how Parkinson's disease develops. Mayo Clinic researchers also have identified many genes associated with Parkinson's disease, as well as many risk factors for the disease through epidemiologic studies.

Researchers study potential causes and possible treatments for Parkinson's disease. Doctors also conduct research in deep brain stimulation to treat Parkinson's disease and other movement disorders. You may have the opportunity to participate in research studies or clinical trials.

Read more about research in:

Publications

See a list of publications about Parkinson's disease by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Parkinson's disease. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/health-information/disorders/parkinsons-disease#. Accessed April 3, 2024.
  2. Kellerman RD. Parkinson's disease. In: Conn's Current Therapy 2024. Elsevier; 2024. https://www.clinicalkey.com. Accessed April 3, 2024.
  3. Parkinson's disease: Hope through research. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Parkinsons-Disease-Hope-Through-Research. Accessed April 3, 2024.
  4. Loscalzo J, et al., eds. Parkinson's disease. In: Harrison's Principles of Internal Medicine. 21st ed. McGraw Hill; 2022. https://accessmedicine.mhmedical.com. Accessed April 4, 2024.
  5. Stoker TB, et al. Parkinson's disease: Pathogenesis and clinical aspects. htps://pubmed.ncbi.nlm.nih.gov/30702835/. Accessed April 4, 2024.
  6. Ferri FF. Parkinson disease. In: Ferri's Clinical Advisor 2022. Elsevier; 2022. https://www.clinicalkey.com. Accessed April 4, 2024.
  7. Jankovic J, et al. Epidemiology, pathogenesis, and genetics of Parkinson disease. https://www.uptodate.com/contents/search. Accessed April 4, 2024.
  8. Berg D, et al. Alpha-synuclein seed amplification and its uses in Parkinson's disease. The Lancet Neurology. 2023; doi:10.1016/S1474-4422(23)00124-2.
  9. Siderowf A, et al. Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using alpha-synuclein seed amplification: A cross-sectional study. The Lancet Neurology. 2023; doi:10.1016/S1474-4422(23)00109-6.
  10. Post B, et al. Young onset Parkinson's disease: A modern and tailored approach. Journal of Parkinson's Disease. 2020; doi:10.3233/JPD-202135.
  11. Ask Mayo Expert. Parkinson disease. Mayo Clinic; 2023.
  12. Caproni S, et al. Diagnosis and differential diagnosis of Parkinson disease. Clinics in Geriatric Medicine. 2020; 10.1016/j.cger.2019.09.014.
  13. Chou KL. Diagnosis and differential diagnosis of Parkinson disease. https://www.uptodate.com/contents/search. Accessed April 8, 2024.
  14. Medical review (expert opinion). Mayo Clinic. May 16, 2023.
  15. Spindler MA, et al. Initial pharmacologic treatment of Parkinson disease. https://www.uptodate.com/contents/search. Accessed April 8, 2024.
  16. Hauser RA, et al. Orally inhaled levodopa (CVT-301) for early morning OFF periods in Parkinson's disease. Parkinsonism and Related Disorders. 2019; doi:10.1016/j.parkreldis.2019.03.026.
  17. Mishima T, et al. Personalized medicine in Parkinson's disease: New options for advanced treatments. Journal of Personalized Medicine. 2021; doi:10.3390/jpm11070650.
  18. Jenner P, et al. Istradefylline — A first adenosine A2A antagonist for the treatment of Parkinson's disease. Expert Review of Neurotherapeutics. 2021; doi:10.1080/14737175.2021.1880896.
  19. Isaacson SH, et al. Blinded SAPS-PD assessment after 10 weeks of pimavanserin treatment for Parkinson's disease psychosis. Journal of Parkinson's Disease. 2020; doi:10.3233/JPD-202047.
  20. Al-Shorafat DM, et al. β-blocker-induced tremor. Movement Disorders Clinical Practice. 2021; doi:10.1002/mdc3.13176.
  21. Taghizadeh M, et al. The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial. Neurochemistry International. 2017; doi:10.1016/j.neuint.2017.03.014.
  22. Parkinson's disease: Fitness counts. Parkinson's Foundation. http://www.parkinson.org/pd-library/books/fitness-counts. Accessed April 9, 2024.Green tea. Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed April 9, 2024.
  23. Relaxation techniques for health. National Center for Complementary and Integrative Health. https://nccih.nih.gov/health/stress/relaxation.htm. Accessed April 9, 2024.
  24. Haahr A, et al. 'Striving for normality' when coping with Parkinson's disease in everyday life. A metasynthesis. International Journal of Nursing Studies. 2021; doi:10.1016/j.ijnurstu.2021.103923.
  25. Mehanna R, et al. Age cutoff for early-onset Parkinson's disease: Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early-Onset Parkinson's Disease. Movement Disorders Clinical Practice. 2022; doi:10.1002/mdc3.13523.
  26. Nimmagadda R, Allscripts EPSi. Mayo Clinic. May 13, 2024.
  27. Siderowf A, et al. Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: A cross-sectional study. The Lancet Neurology. 2023; doi:10.1016/S1474-4422(23)00109-6.
  28. McKnight S, et al. Toxin-induced Parkinsonism. Neurologic Clinics. 2020; doi:10.1016/j.ncl.2020.08.003.