Tests and procedures used to diagnose lip cancer include:

  • Physical exam. During a physical exam, your doctor will examine your lip, mouth, face and neck to look for signs of cancer. Your doctor will ask you about your signs and symptoms.
  • Removing a sample of tissue for testing. During a biopsy, your doctor will remove a small sample of tissue for laboratory testing. In the laboratory, a doctor who analyzes body tissue (pathologist) can determine whether cancer is present, the type of cancer and the level of aggressiveness that's present in the cancer cells.
  • Imaging tests. Imaging tests may be used to determine whether cancer has spread beyond the lip. Imaging tests may include computerized tomography (CT), magnetic resonance imaging (MRI) or positron emission tomography (PET).


Lip cancer treatments include:

  • Surgery. Surgery is used to remove the lip cancer and a margin of healthy tissue that surrounds it. The surgeon then repairs the lip to allow for normal eating, drinking and speaking. Techniques to minimize scarring also are used.

    For small lip cancers, repairing the lip after surgery may be a simple procedure. But for larger lip cancers, skilled plastic and reconstructive surgeons may be needed to repair the lip. Reconstructive surgery may involve moving tissue and skin to the face from another area of the body.

    Surgery for lip cancer may also involve removing cancerous lymph nodes in the neck.

  • Radiation therapy. Radiation therapy uses powerful energy beams, such as X-rays and protons, to kill cancer cells. Radiation therapy for lip cancer may be used on its own or it may be used after surgery. The radiation may be aimed only at your lip, or it may also be aimed at the lymph nodes in your neck.

    Radiation therapy for lip cancer most often comes from a large machine that precisely focuses the energy beams. But in some cases, the radiation can be placed directly on your lip and left in place for a short time. This procedure, called brachytherapy, allows doctors to use higher doses of radiation.

  • Chemotherapy. Chemotherapy uses powerful drugs to kill cancer cells. For lip cancer, chemotherapy is sometimes used in combination with radiation therapy to increase the effectiveness of treatment. In cases of advanced lip cancer that has spread to other areas of the body, chemotherapy may be used to reduce signs and symptoms and make you more comfortable.