Infant jaundice

Infant jaundice is the yellow coloring of a newborn baby's skin and eyes. It's caused by a buildup of pigment called bilirubin in the baby's blood.

Infant jaundice is a common condition, especially in babies born before 37 weeks' gestation (preterm babies) and some breastfed babies. It usually happens because a baby's liver isn't mature enough to get rid of bilirubin (bil-ih-ROO-bin) in the bloodstream. In some babies, an underlying disease may cause infant jaundice.

Most infants born between 35 weeks' gestation and full term need no treatment for jaundice. Rarely, an unusually high blood level of bilirubin can place a newborn at risk of brain damage, particularly in the presence of certain risk factors for serious jaundice.

Yellowing of the skin and the whites of the eyes — the main sign of infant jaundice — usually appears within a few days after birth.

To check for infant jaundice, press gently on your baby's forehead or nose. If the skin looks yellow where you pressed, it's likely your baby has mild jaundice. If your baby doesn't have jaundice, the skin color should simply look slightly lighter than its usual color for a moment.

Examine your baby in good lighting conditions, preferably in natural daylight.

Most hospitals have a policy of examining babies for jaundice before discharge. The American Academy of Pediatrics recommends that:

• Newborns be examined for jaundice during routine medical checks and at least every 12 hours while in the hospital.
• A newborn's bilirubin levels should be checked between 24 and 48 hours after birth.

The following symptoms may suggest complications from too much bilirubin. Call a healthcare professional if:

• Your baby's skin becomes more yellow.
• The skin on your baby's belly, arms or legs looks yellow.
• The whites of your baby's eyes look yellow.
• Your baby seems listless or sick or is hard to wake up.
• Your baby isn't gaining weight or is feeding poorly.
• Your baby makes high-pitched cries.
• Your baby develops any other symptoms that concern you.

Excess bilirubin, called hyperbilirubinemia, is the main cause of jaundice. Bilirubin is a yellow-pigmented substance released into the bloodstream when red blood cells break down.

Newborns produce more bilirubin than adults do. This is due to greater production and faster breakdown of red blood cells in the first few days of life. Typically, the liver filters bilirubin from the bloodstream and releases it into the intestinal tract. A newborn's immature liver often can't remove bilirubin quickly enough. This causes a buildup of bilirubin. Jaundice caused by these typical newborn conditions is called physiologic jaundice, and it typically appears on the second or third day of life.

Other causes

An underlying condition may cause infant jaundice. In these cases, jaundice often appears much earlier or much later than does the more common form of infant jaundice. Conditions that can cause jaundice include:

• Internal bleeding, called hemorrhage.
• An infection in your baby's blood, called sepsis.
• Other viral or bacterial infections.
• An incompatibility between the mother's blood and the baby's blood.
• A liver malfunction.
• Biliary atresia, a condition in which the baby's tubes that connect to the liver, called bile ducts, are blocked or scarred.
• An enzyme deficiency.
• An issue with your baby's red blood cells that causes them to break down rapidly.

Major risk factors for jaundice, particularly severe jaundice that can cause complications, include:

• Premature birth. A baby born before 37 weeks of gestation may not be able to process bilirubin as quickly as full-term babies do. Premature babies also may feed less and have fewer bowel movements, resulting in less bilirubin removed through stool.
• Significant bruising during birth. Newborns who become bruised during delivery may have higher levels of bilirubin from the breakdown of more red blood cells.
• Blood type. If the mother's blood type is different from her baby's, the baby may have received antibodies through the placenta that cause rapid breakdown of red blood cells.
• Breastfeeding. Babies who are breastfed, particularly those who have difficulty nursing or getting enough nutrition from breastfeeding, are at higher risk of jaundice. Dehydration or a low caloric intake may contribute to the onset of jaundice. However, because of the benefits of breastfeeding, experts still recommend it. It's important to make sure your baby gets enough to eat and is adequately hydrated.
• A family history of certain blood disorders. Having a family member with certain blood conditions, such as glucose-6-phosphate dehydrogenase [G6PD] deficiency, increases a baby's risk of having jaundice.
• A parent or sibling who was treated for jaundice. If a family member had jaundice, your baby's risk of jaundice is higher.
• Down syndrome. Newborns with Down syndrome have a higher risk of developing serious jaundice.
• Being a larger-than-average baby with a mother who has diabetes. Larger babies are commonly associated with diabetic pregnancies. Jaundice happens in 10% to 30% of babies of mothers with diabetes. The risk is even higher in babies born before 37 weeks' gestation.

High levels of bilirubin that cause severe jaundice can cause serious complications if not treated.

Acute bilirubin encephalopathy

Bilirubin is toxic to cells of the brain. If a baby has severe jaundice, there's a risk of bilirubin passing into the brain, a condition called acute bilirubin encephalopathy. Prompt treatment may prevent significant lasting damage.

Signs of acute bilirubin encephalopathy in a baby with jaundice include:

• Listlessness.
• Difficulty waking.
• High-pitched crying.
• Poor sucking or feeding.
• Backward arching of the neck and body.
• Fever.

Kernicterus

Kernicterus is the syndrome that happens if acute bilirubin encephalopathy causes permanent damage to the brain. Kernicterus may result in:

• Movements that are not controlled or intended,, known as athetoid cerebral palsy.
• Permanent upward gaze.
• Hearing loss.
• Improper development of tooth enamel.

The best preventive of infant jaundice is adequate feeding. Breastfed infants should have 8 to 12 feedings a day for the first several days of life.