Indigestion

By Mayo Clinic Staff
July 04, 2025

Research

Researchers at Mayo Clinic are working to develop improved treatments for functional indigestion.

Researchers in the Enteric Neuroscience Program are studying the mechanics of the digestive system, including nerve reflexes between the stomach and the brain. Other areas of research include the role of genetics in indigestion and the use of new medicines to reduce stomach sensitivity.

Publications

See a list of publications about indigestion by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. Another term for indigestion is dyspepsia.

  1. Indigestion (dyspepsia). National Institute of Diabetes and Digestive and Kidney Disease. https://www.niddk.nih.gov/health-information/digestive-diseases/indigestion-dyspepsia. Accessed March 3, 2025.
  2. Olson CG, et al. Current opinion: Functional dyspepsia. Current Opinion in Gastroenterology. 2024; doi:10.1097/MOG.0000000000001045.
  3. Lacy BE, et al. The treatment of functional dyspepsia: Present and future. Expert Review of Gastroenterology & Hepatology. 2023; doi:10.1080/17474124.2023.2162877.
  4. Ferri FF. Dyspepsia, nonulcerative. In: Ferri's Clinical Advisor 2025. Elsevier; 2025. https://www.clinicalkey.com. Accessed March 3, 2025.
  5. Kellerman RD, et al. Gaseousness, indigestion, nausea, and vomiting. In: Conn's Current Therapy 2025. Elsevier; 2025. https://www.clinicalkey.com. Accessed March 3, 2025.
  6. Goldman L, et al., eds. Approach to the patient with gastrointestinal disease. In: Goldman-Cecil Medicine. 27th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed March 3, 2025.
  7. Dyspepsia. Merck Manual Professional Version. https://www.merckmanuals.com/professional/gastrointestinal-disorders/symptoms-of-gastrointestinal-disorders/dyspepsia. Accessed March 3, 2025.
  8. Feldman M, et al., eds. Dyspepsia. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 11th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed March 3, 2025.
  9. Amerikanou C, et al. Food, dietary patterns, or is eating behavior to blame? Analyzing the nutritional aspects of functional dyspepsia. Nutrients. 2023; doi10.3390/nu15061544.
  10. Nimmagadda R. Allscripts EPSi. Mayo Clinic. Dec. 2, 2024.
  11. Medical review (expert opinion). Mayo Clinic. March 18, 2025.
  12. Ali RAR, et al. Review of recent evidence on the management of heartburn in pregnant and breastfeeding women. BMC Gastroenterology. 2022; doi:10.1186/s12876-022-02287-w.