Find out whether your risk factors for heart disease make you a good candidate for statin therapy.By Mayo Clinic Staff
Statins are drugs that can lower your cholesterol. They work by blocking a substance your body needs to make cholesterol.
Lowering cholesterol isn't the only benefit associated with statins. These medications have also been linked to a lower risk of heart disease and stroke. These drugs may help stabilize the plaques on blood vessel walls and reduce the risk of certain blood clots.
A number of statins are available for use in the United States. They include:
- Atorvastatin (Lipitor)
- Lovastatin (Altoprev)
- Pitavastatin (Livalo, Zypitamag)
- Pravastatin (Pravachol)
- Rosuvastatin (Crestor, Ezallor)
- Simvastatin (Zocor)
Sometimes, a statin is combined with another heart medication. Examples are atorvastatin-amlodipine (Caduet) and ezetimibe-simvastatin (Vytorin).
Whether you need to be on a statin depends on your cholesterol levels and other risk factors for heart and blood vessel (cardiovascular) disease. Your doctor will consider all of your risk factors for heart attacks and strokes before prescribing a statin.
Knowing your cholesterol numbers is a good place to start.
- Total cholesterol. Most people should try to keep their total cholesterol below 200 milligrams per deciliter (mg/dL), or 5.2 millimoles per liter (mmol/L).
- Low-density lipoprotein (LDL) cholesterol. Aim to keep this "bad" cholesterol under 100 mg/dL, or 2.6 mmol/L. If you have a history of heart attacks or you're at a very high risk of a heart attack or stroke, you may need to aim even lower (below 70 mg/dL, or 1.8 mmol/L).
The most important thing your doctor will keep in mind when thinking about statin treatment is your long-term risk of a heart attack or stroke. If your risk is very low, you probably won't need a statin, unless your LDL is above 190 mg/dL (4.92 mmol/L).
If your risk is very high — for example, you've had a heart attack in the past — a statin may be helpful even if you don't have high cholesterol.
Besides cholesterol, other risk factors for heart disease and stroke are:
- Tobacco use
- Lack of exercise
- High blood pressure
- Overweight or obesity
- Narrowed arteries in your neck, arms or legs (peripheral artery disease)
- Family history of heart disease, especially if it was before the age of 55 in male relatives or before 65 in female relatives
- Older age
Your doctor may use an online tool or calculator to better understand your long-term risks of developing heart disease and whether a statin may be right for you. These tools can help your doctor predict your chances of having a heart attack in the next 10 to 30 years. The formulas in these tools often consider your cholesterol levels, age, race, sex, smoking habits and health conditions.
Not everyone with a heart condition needs to use a statin. Guidelines from the U.S. Preventive Services Task Force, American College of Cardiology and American Heart Association suggest four main groups of people who may be helped by statins:
- People who don't have heart or blood vessel disease, but have one or more cardiovascular disease risk factors and a higher 10-year risk of a heart attack. This group includes people who have diabetes, high cholesterol or high blood pressure, or who smoke and whose 10-year risk of a heart attack is 10% or higher.
- People who already have cardiovascular disease related to hardening of the arteries. This group includes people who have had heart attacks, strokes caused by blockages in a blood vessel, ministrokes (transient ischemic attacks), peripheral artery disease, or prior surgery to open or replace coronary arteries.
- People who have very high LDL ("bad") cholesterol. This group includes adults who have LDL cholesterol levels of 190 mg/dL (4.92 mmol/L) or higher.
- People who have diabetes. This group includes adults 40 to 75 who have diabetes and an LDL cholesterol level between 70 and 189 mg/dL (1.8 and 4.9 mmol/L), especially if they have evidence of blood vessel disease or other risk factors for heart disease such as high blood pressure or smoking.
The U.S. Preventive Services Task Force recommends low- to moderate-dose statins in adults ages 40 to 75 who have one or more risk factors for heart and blood vessel disease and at least a 1 in 10 chance of having a cardiosvascular disease event in the next 10 years.
Lifestyle changes are key for reducing your risk of heart disease, whether you take a statin or not. To reduce your risk:
- Quit smoking and avoid secondhand smoke
- Eat a healthy diet rich in vegetables, fruits, fish and whole grains and low in saturated fat, trans fat, refined carbohydrates and salt
- Be physically active more often and sit less
- Maintain a healthy weight
If your cholesterol — particularly the LDL ("bad") type — stays high after you make healthy lifestyle changes, statins might be an option for you.
You may think that if your cholesterol goes down, you don't need a statin anymore. But if the drug helped lower your cholesterol, you'll likely need to stay on it long term to keep your cholesterol down. If you make significant changes to your diet or lose a lot of weight, talk to your doctor about whether it might be possible to control your cholesterol without medication.
Statins are tolerated well by most people, but they can have side effects. Some side effects go away as the body adjusts to the medication.
But tell your doctor about any unusual signs or symptoms you might have after starting statin therapy. Your doctor may want to decrease your dose or try a different statin. Never stop taking a statin without talking to your doctor first.
Commonly reported side effects of statins include:
- Muscle and joint aches
However, studies comparing statins to a fake pill (placebo) have found a very small difference in the number of people reporting muscle aches between the groups.
Rarely, statins can cause more-serious side effects such as:
- Increased blood sugar or type 2 diabetes. It's possible that your blood sugar (blood glucose) level may slightly increase when you take a statin, which can lead to type 2 diabetes. This is especially likely if your blood sugar is already high. However, the benefit of taking a statin may outweigh that risk. People with diabetes who take statins have much lower risks of heart attacks.
- Muscle cell damage. Very rarely, high-dose statin use can cause muscle cells to break down and release a protein called myoglobin into the bloodstream. This can lead to severe muscle pain and kidney damage.
- Liver damage. Occasionally, statin use causes an increase in liver enzymes. If the increase is mild, you can continue to take the drug. Low to moderate doses of statins don't appear to severely raise liver enzyme levels.
- Memory problems. Some people have reported memory loss and thinking problems after using statins. But a number of studies haven't been able to find any evidence to prove that statins actually cause these difficulties. Other studies suggest that statins may help prevent these issues.
Also, ask your doctor if the statin you use will interact with any other prescription or over-the-counter drugs or supplements you take.
When thinking about whether you should take statins for high cholesterol, ask yourself these questions:
- Do I have other risk factors for heart and blood vessel disease?
- Am I willing and able to make lifestyle changes to improve my health?
- Am I concerned about taking a pill every day, perhaps for the rest of my life?
- Am I concerned about statins' side effects or interactions with other drugs?
It's important to consider your medical reasons, personal values, lifestyle choices and any concerns when choosing a treatment. Talk to your doctor about your total risk of heart and blood vessel disease and personal preferences before making a decision about statin therapy.
July 22, 2021
- Cholesterol medications. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/prevention-and-treatment-of-high-cholesterol-hyperlipidemia/cholesterol-medications. Accessed Jan. 27, 2020.
- Rosenson RS. Statins: Actions, side effects, and administration. https://www.uptodate.com/contents/search. Accessed Jan. 30, 2020.
- Ferri FF. Hypercholesterolemia. In: Ferri's Clinical Advisor 2020. Elsevier; 2020. https://www.clinicalkey.com. Accessed Jan. 30, 2020.
- Kellerman RD, et al. Hyperlipidemia. In: Conn's Current Therapy 2020. Elsevier; 2020. https://www.clinicalkey.com. Accessed Jan. 30, 2020.
- Adhyaru BB, et al. Safety and efficacy of statin therapy. Nature Reviews — Cardiology. 2019; doi:10.1038/s41569-018-0098-5.
- High blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/high-blood-cholesterol. Accessed Jan. 27, 2020.
- US Preventive Services Task Force, et al. Statin use for the primary prevention of cardiovascular disease in adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2016; doi:10.1001/jama.2016.15450.
- Listen to your heart: Learn about heart disease. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/education-and-awareness/heart-truth/listen-to-your-heart. Accessed Jan. 27, 2020.
- Grundy SM, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol. Journal of the American College of Cardiology. 2018; doi:10.1016/j.jacc.2018.11.003.
- Thanassoulis G, et al. A long-term benefit approach vs standard risk-based approaches for statin eligibility in primary prevention. JAMA Cardiology. 2018; doi:10.1001/jamacardio.2018.3476.
- AskMayoExpert. Statin intolerance. Mayo Clinic; 2019.
- Lopez-Jimenez F (expert opinion). Mayo Clinic. Feb. 10, 2020.