Heart valve disease

By Mayo Clinic Staff
May 02, 2026

Research

Mayo Clinic doctors have been pioneers in heart valve surgery, such as mitral valve repair and aortic valve repair, for many years. Mayo researchers study new ways to repair or replace heart valves using catheter procedures, minimally invasive heart surgery and other surgical methods.

Areas of research have included:

  • Development of human biological tissue valves for potential use in heart valve replacement.
  • Minimally invasive and robotic heart surgery to repair or replace heart valves.
  • 3D printing of models of the heart and valves to help doctors prepare for heart valve surgery.
  • Use of blood thinners in people with biological and mechanical tissue valves.
  • Genetics of heart valve disease.

You might have the opportunity to participate in clinical trials. Read more about research in the Cardiovascular Research Center.

Publications

See a list of publications about heart valve disease by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. What are heart valve diseases? National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/heart-valve-diseases. Accessed June 24, 2023.
  2. Nishimura RA, et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2017; doi:10.1016/j.jacc.2017.03.011.
  3. Nimmagadda R. Allscripts EPSi. Mayo Clinic. Feb. 26, 2025.
  4. AskMayoExpert. Mitral regurgitation (adult). Mayo Clinic; 2024.
  5. AskMayoExpert. Aortic stenosis (adult). Mayo Clinic; 2021.
  6. Libby P, et al., eds. Transcatheter therapies for mitral and tricuspid valvular heart disease. In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed June 26, 2023.
  7. Pregnancy and heart valve diseases. American Heart Association. https://www.nhlbi.nih.gov/health/heart-valve-diseases/pregnancy. Accessed March 27, 2025.
  8. Otto CM, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: Executive summary. Circulation. 2021; doi:10.1161/CIR.0000000000000932.
  9. Otto CM, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2021; doi:10.1016/j.jacc.2020.11.018.
  10. Medical review (expert opinion). Mayo Clinic. Sept. 30, 2021.
  11. Lloyd-Jones DM, et al. Life's essential 8: Updating and enhancing the American Heart Association's construct of cardiovascular health: A presidential advisory from the American Heart Association. Circulation. 2022; doi:10.1161/CIR.0000000000001078.
  12. American Heart Association adds sleep to cardiovascular health checklist. American Heart Association. https://newsroom.heart.org/news/american-heart-association-adds-sleep-to-cardiovascular-health-checklist. Accessed July 15, 2022.
  13. Options for heart valve replacement. American Heart Association. https://www.heart.org/en/health-topics/heart-valve-problems-and-disease/understanding-your-heart-valve-treatment-options/options-for-heart-valve-replacement. Accessed June 22, 2023.
  14. Arghami A, et al. Robotic mitral valve repair: A decade of experience with echocardiographic follow-up. Annals of Thoracic Surgery. 2022; doi:10.1016/j.athoracsur.2021.08.083.
  15. Medical review (expert opinion). Mayo Clinic. June 29, 2023.