Gastroesophageal reflux disease (GERD)

By Mayo Clinic Staff
April 23, 2025

Research

Mayo Clinic research scientists and doctors are continually testing new methods for diagnosing and treating GERD. Specific efforts involve the prevalence and prediction of GERD complications, and high-resolution esophageal impedance manometry as a diagnostic tool.

Publications

See a list of publications about GERD by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Maret-Ouda J, et al. Gastroesophageal reflux disease: A review. JAMA. 2020; doi:10.1001/jama.2020.21360.
  2. Katz PO, et al. ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease. American Journal of Gastroenterology. 2022; doi:10.14309/ajg.0000000000001538.
  3. Acid reflux (GER and GERD) in adults. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/digestive-diseases/acid-reflux-ger-gerd-adults. Accessed April 13, 2022.
  4. Kahrilas PJ. Clinical manifestations and diagnosis of gastroesophageal reflux in adults. https://www.uptodate.com/contents/search. Accessed April 13, 2022.
  5. AskMayoExpert. Gastroesophageal reflux disease (GERD) (adult). Mayo Clinic. 2021.
  6. Townsend CM Jr, et al. Gastroesophageal reflux disease and hiatal hernia. In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 21st ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed April 13, 2022.
  7. Feldman M, et al., eds. Gastroesophageal reflux disease. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 11th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed April 13, 2022.
  8. Kahrilas PJ. Medical management of gastroesophageal reflux in adults. https://www.uptodate.com/contents/search. Accessed April 13, 2022.
  9. Winter HS. Management of gastroesophageal reflux disease in children and adolescents. https://www.uptodate.com/contents/search. Accessed April 13, 2022.
  10. Ami TR. Allscripts EPSi. Mayo Clinic. April 7, 2022.
  11. Medical review (expert opinion). Mayo Clinic. May 1, 2022.
  12. Patel A, et al. AGA clinical practice update on integrating potassium-competitive acid blockers into clinical practice: Expert review. Gastroenterology. 2024; doi:10.1053/j.gastro.2024.06.038.
  13. Zdrhova L, et al. Breathing exercises in gastroesophageal reflux disease: A systematic review. Dysphagia. 2023; doi:10.1007/s00455-022-10494-6.
  14. Medical review (expert opinion). Mayo Clinic. March 10, 2025.