Eosinophilic esophagitis

July 02, 2024

Research

Mayo Clinic is a leader in eosinophilic esophagitis research and actively researches eosinophilic disorders. Clinical trials are underway to study long-term management and remission of eosinophilic esophagitis.

Mayo Clinic researchers are also studying the use of a device called the Cytosponge as a replacement for endoscopy to monitor ongoing treatment for eosinophilic esophagitis. The Cytosponge is a small sponge inside a capsule attached to a string. You swallow the capsule, which dissolves; the doctor then pulls out the sponge, scraping cells off your esophagus. It's quick, inexpensive, minimally invasive and does not require anesthesia.

The Allergic Diseases Research Laboratory at Mayo Clinic's campus in Rochester, Minnesota, investigates the mechanisms of common airway and skin diseases. The lab focuses on and studies types of immune cells, especially eosinophils, a type of white blood cell. Laboratories in the areas of clinical immunology and immunotherapeutics, immunology, and gastroenterology and hepatology also are involved in research on eosinophilic disorders.

Publications

See a list of publications about eosinophilic esophagitis by Mayo doctors on PubMed, a service of the National Library of Medicine.

  1. Surdea-Blaga T, et al. Eosinophilic esophagitis: Diagnosis and current management. Journal of Gastrointestinal and Liver Diseases. 2020; doi:10.15403/jgld-768.
  2. Spechler SJ. Eosinophilic esophagitis: Novel concepts regarding pathogenesis and clinical manifestations. Journal of Gastroenterology. 2019; doi:10.1007/s00535-019-01604-7.
  3. Eosinophilic esophagitis. American Partnership for Eosinophilic Disorders. https://apfed.org/about-ead/egids/eoe/#:~:text=Eosinophilic%20esophagitis%20(EoE)%20is%20a,and%20inflammation%20to%20the%20esophagus. Accessed Aug. 26, 2022.
  4. Eosinophilic esophagitis in pediatric and adolescent patients. American College of Gastroenterology. https://gi.org/topics/eosinophilic-esophagitis-in-pediatric-and-adolescent-patients/#:~:text=Infants%20and%20toddlers%20with%20EoE,)%2C%20especially%20with%20solid%20meals. Accessed Aug. 26, 2022.
  5. Gómez-Aldana A, et al. Eosinophilic esophagitis: Current concepts in diagnosis and treatment. World Journal of Gastroenterology. 2019; doi:10.3748/wjg.v25.i32.4598.
  6. Acid reflux. American College of Gastroenterology. https://gi.org/topics/acid-reflux/. Accessed Aug. 26, 2022.
  7. Nguyen HT. Allscripts EPSi. Mayo Clinic. March 30, 2022.
  8. Medical review (expert opinion). Mayo Clinic. Aug. 26, 2022.
  9. Muñoz-Bellido FJ, et al. Dupilumab: A review of present indications and off-label uses. Journal of Investigational Allergology and Clinical Immunology. 2022; doi:10.18176/jiaci.0682.