Diagnosis

An enlarged spleen is usually detected during a physical exam. Your doctor can often feel it by gently examining your left upper abdomen. However, in some people — especially those who are slender — a healthy, normal-sized spleen can sometimes be felt during an exam.

Your doctor may confirm the diagnosis of an enlarged spleen with one or more of these tests:

  • Blood tests, such as a complete blood count to check the number of red blood cells, white blood cells and platelets in your system
  • Ultrasound or computerized tomography (CT) scan to help determine the size of your spleen and whether it's crowding other organs
  • Magnetic resonance imagining (MRI) to trace blood flow through the spleen

Imaging tests aren't always needed to diagnose an enlarged spleen. But if your doctor recommends imaging, you generally don't need any special preparation for an ultrasound or MRI.

If you're having a CT scan, however, you may need to refrain from eating before the test. If you need to prepare, your doctor will let you know well in advance.

Finding the cause

Sometimes you may need more testing to find the cause of an enlarged spleen, including liver function tests and a bone marrow exam. These tests can provide more-detailed information about your blood cells than can blood drawn from a vein.

A sample of solid bone marrow is sometimes removed in a procedure called a bone marrow biopsy. Or you may have a bone marrow aspiration, which removes the liquid portion of your marrow. In many cases, both procedures are performed at the same time (bone marrow exam).

Both the liquid and solid bone marrow samples are usually taken from the pelvis. A needle is inserted into the bone through an incision. You'll receive either general or local anesthesia before the test to ease discomfort.

A needle biopsy of the spleen is very rare because of the risk of bleeding.

Occasionally, your doctor may recommend surgery to remove your spleen when there's no identifiable cause for the enlargement. After surgical removal, the spleen is examined under a microscope to check for possible lymphoma of the spleen.

Treatment

Treatment for an enlarged spleen focuses on the underlying problem. For example, if you have a bacterial infection, treatment will include antibiotics.

Watchful waiting

If you have an enlarged spleen but don't have any symptoms and the cause can't be found, your doctor may suggest watchful waiting. You'll have to see your doctor for reevaluation in six to 12 months or sooner if you develop any symptoms.

Spleen removal surgery

If an enlarged spleen causes serious complications or the cause can't be identified or treated, surgical removal of your spleen (splenectomy) may be an option. In chronic or critical cases, surgery may offer the best hope for recovery.

Elective spleen removal requires careful consideration. You can live an active life without a spleen, but you're more likely to contract serious or even life-threatening infections after spleen removal. Sometimes radiation can shrink your spleen so that you can avoid surgery.

Reducing infection risk after surgery

After spleen removal, certain steps can help reduce your risk of infection, including:

  • A series of vaccinations both before and after the splenectomy. These include the pneumococcal (Pneumovax 23), meningococcal and haemophilus influenzae type b (Hib) vaccines, which protect against pneumonia, meningitis and infections of the blood, bones and joints. You'll also need the pneumococcal vaccine every five years after surgery.
  • Taking penicillin or other antibiotics after your operation and anytime you or your doctor suspects the possibility of an infection.
  • Calling your doctor at the first sign of a fever, because this may indicate an infection.
  • Avoiding travel to parts of the world where certain diseases, such as malaria, are common.

Lifestyle and home remedies

Avoid contact sports — such as soccer, football and hockey — and limit other activities as recommended by your doctor. Modifying your activities can reduce the risk of a ruptured spleen.

It's also important to wear a seat belt. If you're in a car accident, a seat belt can help prevent injury to your spleen.

Finally, be sure to keep your vaccinations up to date because your risk of infection is increased. That means at least an annual flu shot, and a tetanus, diphtheria and pertussis booster every 10 years. Ask your doctor if you need any additional vaccines.