There's no single test to confirm a diagnosis of chronic fatigue syndrome. Symptoms can mimic those of many other health problems, including:
- Sleep disorders. Chronic fatigue can be caused by sleep disorders. A sleep study can determine if your rest is being disturbed by disorders such as obstructive sleep apnea, restless legs syndrome or insomnia.
- Medical problems. Fatigue is a common symptom in several medical conditions, such as anemia, diabetes and underactive thyroid (hypothyroidism). Lab tests can check your blood for evidence of some of the top suspects.
- Mental health issues. Fatigue is also a symptom of a variety of mental health problems, such as depression and anxiety. A counselor can help determine if one of these problems is causing your fatigue.
It's also common for people who have chronic fatigue syndrome to also have other health problems at the same time, such as sleep disorders, irritable bowel syndrome, fibromyalgia, depression or anxiety.
In fact, there are so many overlapping symptoms between chronic fatigue syndrome and fibromyalgia that some researchers consider the two disorders to be different aspects of the same disease.
Guidelines proposed by the United States Institute of Medicine define the fatigue associated with chronic fatigue syndrome as being:
- So severe that it interferes with the ability to engage in pre-illness activities
- Of new or definite onset (not lifelong)
- Not substantially alleviated by rest
- Worsened by physical, mental or emotional exertion
To meet the Institute of Medicine's diagnostic criteria for chronic fatigue syndrome, a person would also need to experience at least one of these two symptoms:
- Difficulties with memory, focus and concentration
- Dizziness that worsens with moving from lying down or sitting to standing
These symptoms must last for at least six months and occur at least half the time at moderate, substantial or severe intensity.
There is no cure for chronic fatigue syndrome. Treatment focuses on symptom relief. The most disruptive or disabling symptoms should be addressed first.
Some problems associated with chronic fatigue syndrome can be improved with either prescription or over-the-counter medications. Examples include:
- Depression. Many people with long-term health problems, such as chronic fatigue syndrome, are also depressed. Treating your depression can make it easier for you to cope with the problems associated with chronic fatigue syndrome. Low doses of some antidepressants can also help improve sleep and relieve pain.
- Orthostatic intolerance. Some people with chronic fatigue syndrome, particularly adolescents, feel faint or nauseated when they stand or sit upright. Medications to regulate blood pressure or heart rhythms may be helpful.
- Pain. If over-the-counter medications such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve) don't help enough, prescription drugs sometimes used to treat fibromyalgia might be options for you. These include pregabalin (Lyrica), duloxetine (Cymbalta), amitriptyline or gabapentin (Neurontin).
Many people with chronic fatigue syndrome benefit from:
- Counseling. Talking with a counselor can help build coping skills to deal with chronic illness, address limitations at work or school, and improve family dynamics. It can also be helpful for managing depression.
- Addressing sleep problems. Sleep deprivation can make other symptoms more difficult to deal with. Your doctor might suggest avoiding caffeine or changing your bedtime routine. Sleep apnea can be treated by using a machine that delivers air pressure through a mask while you sleep.
- Exercise. Aggressive exercise regimens often lead to worsened symptoms, but maintaining activities that are tolerated is important to prevent deconditioning. Exercise regimens that start at a very low intensity and increase very gradually over time may be helpful in improving long-term function.
People with chronic fatigue syndrome have a worsening of their symptoms after physical, mental or emotional effort. This is called post-exertional malaise and it can last for days or weeks after the exertion.
People who experience post-exertional malaise often struggle to find a good balance between activity and rest. The goal is to remain active without overdoing it.
You may want to keep a daily diary of your activities and symptoms, so you can track how much activity is too much for you. This may help you avoid pushing too hard on the days you feel good, which can result in a "crash" where you feel much worse later.
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Many alternative therapies have been promoted for chronic fatigue syndrome, but there's not much evidence that they work. Patients with chronic fatigue syndrome may be sensitive to medications, including herbal products and supplements. Treatments that are expensive or potentially harmful should be avoided.
Coping and support
The experience of chronic fatigue syndrome varies from person to person. Emotional support and counseling may help you and your loved ones deal with the uncertainties and restrictions of this disorder.
You may find it therapeutic to join a support group and meet other people with chronic fatigue syndrome. Support groups aren't for everyone, and you may find that a support group adds to your stress rather than relieves it. Experiment and use your own judgment to determine what's best for you.
Preparing for your appointment
If you have signs and symptoms of chronic fatigue syndrome, you're likely to start by seeing your family doctor or a general practitioner. It can be difficult to absorb all of the information provided during an appointment, so you might want to arrange for a friend or family member to accompany you. Having someone else hear the information can help you later in case there's something you missed or forgot.
What you can do
Before your appointment, you may want to write a list that includes:
- Your signs and symptoms. Be thorough. While fatigue may be affecting you most, other symptoms — such as memory problems or headaches — also are important to share with your doctor.
- Key personal information. Recent changes or major stressors in your life can play a very real role in your physical well-being.
- Health information. List any other conditions for which you're being treated and the names of any medications, vitamins or supplements that you take regularly.
- Questions to ask your doctor. Creating your list of questions in advance can help you make the most of your time with your doctor.
For chronic fatigue syndrome, some basic questions to ask your doctor include:
- What are the possible causes of my symptoms or condition?
- What tests do you recommend?
- If these tests don't pinpoint the cause of my symptoms, what additional tests might I need?
- On what basis would you make a diagnosis of chronic fatigue syndrome?
- Are there any treatments or lifestyle changes that could help my symptoms now?
- Do you have any printed materials I can take with me? What websites do you recommend?
- What activity level should I aim for while we're seeking a diagnosis?
- Do you recommend that I also see a mental health provider?
Don't hesitate to ask other questions during your appointment as they occur to you.
What to expect from your doctor
Your doctor is likely to ask you a number of questions, such as:
- What are your symptoms and when did they begin?
- Does anything make your symptoms better or worse?
- Do you have problems with memory or concentration?
- Are you having trouble sleeping?
- How often do you feel depressed or anxious?
- How much do your symptoms limit your ability to function? For example, have you ever had to miss school or work because of your symptoms?
- What treatments have you tried so far for this condition? How have they worked?