Bipolar disorder

By Mayo Clinic Staff
May 07, 2026

Research

Mayo Clinic's clinical trials are helping to diagnose and treat bipolar disorder. Some areas of research include:

  • Drug treatment options. Mayo Clinic scientists seek to create better and more-targeted drug treatment options based on changes in brain imaging patterns, brain metabolism and genetic makeup.
  • Genetics and medicine. Mayo is a leader in pharmacogenomics research, which is the study of how genetics can predict how a person will respond to a medicine. One focus of Mayo Clinic research is connecting specific genetic profiles with responses to specific antidepressant drugs used to treat depression.

Mayo Clinic is the primary site for the Individualized Medicine Biobank for Bipolar Disorder. This biobank of people with bipolar type I and II is a resource for the bipolar research community. A biobank is a collection of biological or medical data and samples.

Publications

See a list of publications about bipolar disorder by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Bipolar and related disorders. In: Diagnostic and Statistical Manual of Mental Disorders DSM-5-TR. 5th ed. American Psychiatric Association; 2022. https://dsm.psychiatryonline.org. Accessed Jan. 15, 2024.
  2. Bipolar disorder. Substance Abuse and Mental Health Services Administration. https://www.samhsa.gov/mental-health/bipolar. Accessed Jan. 15, 2024.
  3. Roberts LW, et al. Bipolar and related disorders. In: The American Psychiatric Association Publishing Textbook of Psychiatry. 7th ed. American Psychiatric Publishing; 2019. https://psychiatryonline.org. Accessed Jan. 15, 2024.
  4. Kellerman RD, et al. Depressive, bipolar, and related mood disorders. In: Conn's Current Therapy 2024. Elsevier; 2024. https://clinicalkey.com. Accessed Jan. 15, 2024.
  5. Suppes T. Bipolar disorder in adults: Clinical features. https://www.uptodate.com/contents/search. Accessed Jan. 15, 2024.
  6. Miklowitz DJ, et al. Adjunctive psychotherapy for bipolar disorder: A systemic review and component network meta-analysis. JAMA Psychiatry. 2020; doi:10.1001/jamapsychiatry.2020.2993.
  7. Bipolar disorder. National Institute of Mental Health. https://www.nimh.nih.gov/health/topics/bipolar-disorder. Accessed Jan. 15, 2024.
  8. Bipolar disorder in children and teens. National Institute of Mental Health. https://www.nimh.nih.gov/health/publications/bipolar-disorder-in-children-and-teens. Accessed Jan. 15, 2024.
  9. Bipolar disorder. National Alliance on Mental Illness. https://www.nami.org/About-Mental-Illness/Mental-Health-Conditions/Bipolar-Disorder. Accessed Jan. 15, 2024.
  10. Yalin N, et al. Pharmacological treatment of bipolar depression: What are the current and emerging options? Neuropsychiatric Disease and Treatment. 2020; doi:10.2147/NDT.S245166.
  11. Suppes T. Bipolar disorder in adults: Assessment and diagnosis. https://www.uptodate.com/contents/search. Accessed Jan. 15, 2024.
  12. Shelton RC, et al. Bipolar major depression in adults: Choosing treatment. Accessed Jan. 15, 2024.
  13. 988 Suicide & Crisis Lifeline. Substance Abuse and Mental Health Services Administration. https://988lifeline.org/. Accessed Jan. 15, 2024.
  14. Managing stress. National Alliance on Mental Illness. https://www.nami.org/Your-Journey/Individuals-with-Mental-Illness/Taking-Care-of-Your-Body/Managing-Stress. Accessed Jan. 15, 2024.
  15. Axelson D. Pediatric bipolar disorder: Overview of choosing treatment. https://www.uptodate.com/contents/search. Accessed Jan. 15, 2024.
  16. Markdante KJ, et al., eds. Depression and bipolar disorders. In: Nelson Essentials of Pediatrics. 9th ed. Elsevier; 2023. https://www.clinicalkey.com/. Accessed Jan. 15, 2024.
  17. Medical review (expert opinion). Mayo Clinic. April 8, 2024.
  18. Jawad MY, et al. The role of ketamine in the treatment of bipolar depression: A scoping review. Brain Sciences. 2023; doi:10.3390/brainsci13060909.
  19. Dissociative disorders. In: Diagnostic and Statistical Manual of Mental Disorders DSM-5-TR. 5th ed. American Psychiatric Association; 2022. https://dsm.psychiatryonline.org. Accessed Jan. 17, 2024.
  20. Medical review (expert opinion). Mayo Clinic. June 18, 2024.