Benign prostatic hyperplasia (BPH)

By Mayo Clinic Staff
Dec. 23, 2025

Research

Mayo Clinic researchers are working to improve diagnosis and treatment of benign prostatic hyperplasia (BPH). Ongoing studies by Mayo Clinic researchers are exploring minimally invasive technologies to treat BPH, including heat-based treatments such as transurethral microwave thermotherapy; interstitial devices such as interstitial laser coagulation and transurethral needle ablation; high-intensity focused ultrasound; and water-induced thermotherapy.

Read more about BPH research at Mayo Clinic.

Publications

See a list of publications about benign prostatic hyperplasia by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Wein AJ, et al., eds. Benign prostatic hyperplasia: Etiology, pathophysiology, epidemiology, and natural history. In: Campbell-Walsh-Wein Urology. 12th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed Nov. 29, 2022.
  2. Whitley B, et al. Benign prostatic hyperplasia. In: Conn's Current Therapy 2021. Elsevier; 2021. https://www.clinicalkey.com. Accessed Nov. 29, 2022.
  3. Management of benign prostatic hyperplasia/lower urinary tract symptoms (2021). American Urological Association. https://www.auanet.org/guidelines-and-quality/guidelines/benign-prostatic-hyperplasia-(bph)-guideline. Accessed Nov. 29, 2022.
  4. McVary K. Clinical manifestations and diagnostic evaluation of benign prostatic hyperplasia. https://www.uptodate.com/contents/search. Accessed Nov. 29, 2022.
  5. Ferri FF. Benign prostatic hyperplasia. In: Ferri's Clinical Advisor 2023. Elsevier; 2023. https://www.clinicalkey.com. Accessed Nov. 29, 2022.
  6. Wein AJ, et al., eds. Evaluation and nonsurgical management of benign prostatic hyperplasia. In: Campbell-Walsh Urology. 12th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed Nov. 29, 2022.
  7. Townsend CM Jr, et al. Urologic surgery. In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 21st ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Nov. 29, 2022.
  8. McVary K. Surgical treatment of benign prostatic hyperplasia (BPH). https://www.uptodate.com/contents/search. Accessed Nov. 29, 2022.
  9. AskMayoExpert. Benign prostatic hyperplasia. Mayo Clinic; 2022.
  10. Ami T. Allscripts EPSi. Mayo Clinic. Dec. 20, 2022.
  11. Understanding prostate changes: A health guide for men. National Cancer Institute. https://www.cancer.gov/types/prostate/understanding-prostate-changes. Accessed Nov. 30, 2022.
  12. McVary K. Medical treatment of benign prostatic hyperplasia. https://www.uptodate.com/contents/search. Accessed Nov. 29, 2022.
  13. Lee KS, et al. Effect of climatic parameters on acute urinary retention incidence. LUTS: Lower Urinary Tract Symptoms. 2018; doi:10.1111/luts.12184.
  14. Partin AW, et al., eds. Benign prostatic hyperplasia. In: Campbell Walsh Wein Handbook of Urology. Elsevier; 2022. https://www.clinicalkey.com. Accessed Dec. 2, 2022.
  15. Urinary and bladder problems. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/side-effects/urination-changes. Accessed Dec. 2, 2022.
  16. Taneja SS, et al., eds. Complications of endoscopic procedures for benign prostatic hyperplasia. In: Taneja's Complications of Urologic Surgery: Diagnosis, Prevention, and Management. 5th ed. Elsevier; 2018. https://www.clinicalkey.com. Accessed Dec. 2, 2022.
  17. Townsend CM Jr, et al. Urologic surgery. In: Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 21st ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Dec. 2, 2022.
  18. Sandhu JS, et al. Management of lower urinary tract symptoms attributed to benign prostatic hyperplasia (BPH): AUA guideline amendment 2023. The Journal of Urology. 2024; doi:10.1097/JU.0000000000003698.
  19. Sapoval M, et al. Prostatic artery embolization versus medical treatment in patients with benign prostatic hyperplasia (PARTEM): A randomized, multicentre, open-label, phase 3, superiority trial. The Lancet Regional Health — Europe. 2023; doi: 10.1016/j.lanepe.2023.100672.
  20. Bilhim T, et al. Long-term outcome of prostatic artery embolization for patients with benign prostatic hyperplasia: Single-centre retrospective study in 1072 patients over a 10-year period. Cardiovascular and Interventional Radiology. 2022; doi: 10.1007/s00270-022-03199-8.
  21. Pisco JM, et al. Randomised clinical trial of prostatic artery embolization versus a sham procedure for benign prostatic hyperplasia. European Urology. 2020; doi: 10.1016/j.eururo.2019.11.010.