Atrial fibrillation

By Mayo Clinic Staff
Jan. 14, 2026

Research

Mayo Clinic researchers study the genetics, causes, diagnosis and treatment options for atrial fibrillation and other heart rhythm disorders.

Topics of research have included:

  • Artificial intelligence combined with an electrocardiogram (ECG or EKG) to help diagnose atrial fibrillation sooner.
  • Pulsed field ablation for atrial fibrillation.

Learn more about research in the Cardiovascular Research Center.

Publications

See a list of publications about atrial fibrillation by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Atrial fibrillation. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/atrial-fibrillation. Accessed March 23, 2023.
  2. Jalife J, et al., eds. Ablation for atrial fibrillation. In: Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside. 8th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed March 23, 2023.
  3. Ferri FF. Atrial fibrillation. In: Ferri's Clinical Advisor 2023. Elsevier; 2023. https://www.clinicalkey.com. Accessed March 23, 2023.
  4. Attia ZI, et al. An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: A retrospective analysis of outcome prediction. Lancet. 2019; doi:10.1016/S0140-6736(19)31721-0.
  5. Atrial fibrillation. Centers for Disease Control and Prevention. https://www.cdc.gov/heartdisease/atrial_fibrillation.htm. Accessed March 23, 2023.
  6. Kumar K. Overview of atrial fibrillation. https://www.uptodate.com/contents/search. Accessed March 23, 2023.
  7. Bonow RO, et al., eds. Atrial fibrillation: Clinical features, mechanisms and management. In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed March 23, 2023.
  8. January CT, et al. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in collaboration with the Society of Thoracic Surgeons. Circulation. 2019; doi:10.1161/CIR.0000000000000665.
  9. Chung MK, et al. Atrial fibrillation: JACC Council perspectives. Journal of the American College of Cardiology. 2020; doi:10.1016/j.jacc.2020.02.025.
  10. Ponamgi SP, et al. Screening and management of atrial fibrillation in primary care. BMJ. 2021; doi:10.1136/bmj.n379.
  11. Facts about AFib. American Heart Association. https://www.heart.org/en/health-topics/atrial-fibrillation. Accessed March 23, 2023.
  12. Kumar K. Antiarrhythmic drugs to maintain sinus rhythm in patients with atrial fibrillation: Recommendations. https://www.uptodate.com/contents/search. Accessed March 23, 2023.
  13. Kaplan R. Control of ventricular rate in patients with atrial fibrillation who do not have heart failure: Pharmacologic therapy. https://www.uptodate.com/contents/search. Accessed March 23, 2023.
  14. Reddy VY, et al. 5-year outcomes after left atrial appendage closure: From the PREVAIL and PROTECT AF trials. Journal of the American College of Cardiology. 2017; doi:10.1016/j.jacc.2017.10.021.
  15. Ami TR. Allscripts EPSi. Mayo Clinic. Jan. 17, 2025.
  16. Medical review (expert opinion). Mayo Clinic. April 18, 2023.
  17. Guide to atrial fibrillation. Heart Rhythm Society. https://www.hrsonline.org/guide-atrial-fibrillation. Accessed March 23, 2023.
  18. DeLurgio DB, et al. Hybrid convergent procedure for the treatment of persistent and long-standing persistent atrial fibrillation. Circulation: Arrhythmia and Electrophysiology. 2020; doi:10.1161/CIRCEP.120.009288.
  19. Kaba RA, et al. A chronicle of hybrid atrial fibrillation ablation therapy: From Cox maze to convergent. Arrhythmia and Electrophysiology Review. 2022; doi:10.15420/aer.2022.05.
  20. Verma A, et al. Pulsed field ablation for the treatment of atrial fibrillation: PULSED AF pivotal trial. Circulation. 2023; doi:10.1161/CIRCULATIONAHA.123.063988.
  21. Medical review (expert opinion). Mayo Clinic. Feb. 22, 2024.
  22. Artificial intelligence (AI) in cardiovascular medicine. Mayo Clinic. https://www.mayoclinic.org/departments-centers/ai-cardiology/overview/ovc-20486648. Jan. 20, 2025.