Aortic valve disease

By Mayo Clinic Staff
Oct. 06, 2026

Research

Mayo Clinic researchers study diagnostic tests and treatment options for aortic valve disease. Read more about research in the Cardiovascular Research Center.

Areas of research have included:

  • Sutureless valves for aortic valve disease treatment.
  • Valve-sparing aortic root replacement.
  • Imaging techniques to diagnose and monitor valve disease. This includes echocardiography, multidetector computerized tomography and cardiac magnetic resonance imaging.
  • Minimally invasive procedures to treat aortic valve disease, including transcatheter aortic valve replacement, also called TAVR.
  • How well people do after TAVR compared with those who have open-heart surgery.
  • 3D printing to create models of the heart and valves that surgeons may study to prepare for doing heart valve surgery.

Publications

See a list of publications about aortic valve disease by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Libby P, et al., eds. Aortic valve stenosis. In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Feb. 28, 2025.
  2. Buja LM, et al., eds. Valvular heart disease. In: Cardiovascular Pathology. 5th ed. Elsevier; 2022. https://www.clinicalkey.com. Accessed Feb. 28, 2025.
  3. Crawford MH, ed. Aortic stenosis. In: Current Diagnosis & Treatment: Cardiology. 6th ed. McGraw Hill; 2023. https://accessmedicine.mhmedical.com. Accessed Feb. 28, 2025.
  4. Crawford MH, ed. Aortic regurgitation. In: Current Diagnosis & Treatment: 6th ed. McGraw Hill; 2023. https://accessmedicine.mhmedical.com. Accessed Feb. 28, 2025.
  5. Fuster V, et al., eds. Aortic valve disease. In: Hurst's the Heart. 14th ed. McGraw-Hill; 2017. https://accessmedicine.mhmedical.com. Accessed Aug. 7, 2021.
  6. What is heart-healthy living? National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/heart-healthy-living. Accessed Feb. 28, 2025.
  7. What are heart valve diseases? National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health/heart-valve-diseases. Accessed Feb. 28, 2025.
  8. Otto CM, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: Executive summary. Circulation. 2021; doi:10.1161/CIR.0000000000000932.
  9. Nimmagadda R. Allscripts EPSi. Mayo Clinic. Feb. 26, 2025.
  10. Otto CM, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2021; doi:10.1016/j.jacc.2020.11.018.
  11. Medical review (expert opinion). Mayo Clinic. Sept. 30, 2021.
  12. Spadaccio C, et al. Sutureless valves, a "wireless" option for patients with aortic valve disease: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 2024; doi:10.1016/j.jacc.2024.05.031.
  13. Stephens E, et al. Valve-sparing aortic root replacement state-of-the-art review, part I: Anatomy and physiology. Annals of Thoracic Surgery. 2024; doi:10.1016/j.athoracsur.2023.12.018.
  14. Lloyd-Jones DM, et al. Life's essential 8: Updating and enhancing the American Heart Association's construct of cardiovascular health: A presidential advisory from the American Heart Association. Circulation. 2022; doi:10.1161/CIR.0000000000001078.
  15. 2020-2025 Dietary Guidelines for Americans. U.S. Department of Health and Human Services and U.S. Department of Agriculture. https://www.dietaryguidelines.gov. Accessed Feb. 25, 2025.
  16. Physical Activity Guidelines for Americans. 2nd ed. U.S. Department of Health and Human Services. https://health.gov/our-work/physical-activity/current-guidelines. Accessed Feb. 28, 2025.