Attention-deficit/hyperactivity disorder (ADHD) in children

By Mayo Clinic Staff
March 07, 2025

Research

Mayo Clinic's Department of Psychiatry and Psychology does research to compare various treatment models to find the most effective treatments for attention-deficit/hyperactivity disorder (ADHD). This involves analyzing long-term outcomes of children with ADHD. Researchers also are working to identify genes related to medication response in children with ADHD. This can help tailor treatment to the individual needs of the child with ADHD.

Publications

See a list of publications about attention-deficit/hyperactivity disorder (ADHD) in children by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

  1. Neurodevelopmental disorders. In: Diagnostic and Statistical Manual of Mental Disorders DSM-5-TR. 5th ed. American Psychiatric Association; 2022. https://dsm.psychiatryonline.org. Accessed Dec. 2, 2024.
  2. Attention-deficit/hyperactivity disorder. National Institute of Mental Health. https://www.nimh.nih.gov/health/topics/attention-deficit-hyperactivity-disorder-adhd. Accessed Dec. 3, 2024.
  3. Kliegman RM, et al. Psychopharmacology. In: Nelson Textbook of Pediatrics. 22nd ed. Elsevier; 2025. https://www.clinicalkey.com. Accessed Dec. 2, 2024.
  4. Liu H, et al. Screen time and childhood attention deficit hyperactivity disorder: A meta-analysis. Reviews on Environmental Health. 2024; doi:10.1515/reveh-2022-0262.
  5. ADHD and complementary health approaches: What the science says. National Center for Complementary and Integrative Health. https://www.nccih.nih.gov/health/providers/digest/adhd-and-complementary-health-approaches-science#natural-products. Accessed Dec. 5, 2024.
  6. Peterson BS, et al. Treatments for ADHD in children and adolescents: A systematic review. Pediatrics. 2024; doi:10.1542/peds.2024-065787.
  7. Treatment of ADHD. Centers for Disease Control and Prevention. https://www.cdc.gov/adhd/treatment/index.html. Accessed Dec. 5, 2024.
  8. Attention-Deficit /Hyperactivity Disorder (ADHD): Parents' Medication Guide. American Academy of Child and Adolescent Psychiatry. https://www.aacap.org/aacap/Families_and_Youth/Resource_Centers/ADHD_Resource_Center/Home.aspx. Accessed Dec. 5, 2024.
  9. Parenting a child with ADHD. National Resource Center on ADHD. https://chadd.org/for-parents/overview/. Accessed Dec. 5, 2024.
  10. Mechler K, et al. Evidence-based pharmacological treatment options for ADHD in children and adolescents. Pharmacology & Therapeutics. 2022; doi:10.1016/j.pharmthera.2021.107940.
  11. Nanda A, et al. Adverse effects of stimulant interventions for attention deficit hyperactivity disorder (ADHD): A comprehensive systematic review. Cureus. 2023; doi:10.7759/cureus.45995.
  12. Chan E. Attention deficit hyperactivity disorder in children and adolescents: Epidemiology and pathogenesis. https://www.uptodate.com/contents/search. Accessed Dec. 20, 2024.
  13. Monarch eTNS System. NeuroSigma. https://www.monarch-etns.com/. Accessed Dec. 3, 2024.
  14. Garrison-Desany HM, et al. Individual and combined association between prenatal polysubstance exposure and childhood risk of attention-deficit/hyperactivity disorder. JAMA Network Open. 2022; doi:10.1001/jamanetworkopen.2022.1957.
  15. Sugar: Does it really case hyperactivity? Academy of Nutrition and Dietetics. https://www.eatright.org/health/wellness/healthful-habits/sugar-does-it-really-cause-hyperactivity. Accessed Dec. 9, 2024.
  16. Complementary and alternative medicine. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/cam. Accessed Dec. 9, 2024.
  17. Pinto S, et al. Eating patterns and dietary interventions in ADHD: A narrative review. Nutrients. 2022; doi:10-3390/nu14204332.
  18. Golsorkhi H, et al. Herbal medicines in the treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD): An updated systemic review of clinical trials. Avicenna Journal of Phytomedicine. 2023; doi:10.22038/AJP.2022.21115.
  19. Kollins SH, et al. A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): A randomised controlled trial. The Lancet Digital Health. 2020; doi:10.1016/S2589-7500(20)30017-0.
  20. Medical review (expert opinion). Mayo Clinic. Jan. 14, 2025.
  21. EndeavorRx. Akili Interactive Labs, Inc. https://www.endeavorrx.com/about-endeavorrx/. Accessed Jan. 27, 2025.
  22. Allscripts EPSi. Mayo Clinic.