Search for a doctor

Brittany L. Siontis, M.D.

  1. Oncologist
Request an Appointment

Publications

  1. Siontis BL, Rice JD, Schuetze SM, Rottmann D, Angeles CV, Fox AK, Zyczynski LE, Hayek S, Robinson SI, Okuno SH, Ho TP, Chugh R. A Phase II Multicenter Trial of Trabectedin in Combination with Olaparib in Patients with Advanced Unresectable or Metastatic Sarcoma. Clin Cancer Res. 2025 Jul 15; 31 (14):2919-2925
    View PubMed
  2. Heinrich MC, Blay JY, Gelderblom H, George S, Schoffski P, von Mehren M, Zalcberg JR, Jones RL, Kang YK, Razak AA, Trent J, Attia S, Le Cesne A, Boye K, Goldstein D, Sanchez C, Siontis BL, Cox P, Davis E, Sherman ML, Ruiz-Soto R, Bauer S. Updated Overall Survival and Long-Term Safety With Ripretinib Versus Sunitinib in Patients With GI Stromal Tumor: Final Overall Survival Analysis From INTRIGUE. J Clin Oncol. 2025 May 23; JCO2402818 [Epub ahead of print]
    View PubMed
  3. Ahmed SK, Xu-Welliver M, Dorr M, Steinert KO, Houdek MT, Rose PS, Karim SM, Ashman JB, Goulding KA, Siontis BL, Haddock MG, Petersen IA. Hypofractionated Preoperative Radiation Therapy for Extremity and Superficial Trunk Soft Tissue Sarcomas: Results of a Prospective, Phase 2 Trial. Int J Radiat Oncol Biol Phys. 2025 May 17 [Epub ahead of print]
    View PubMed
  4. Kournoutas I, Siontis BL. Minimal Residual Disease in Metastatic Soft Tissue Sarcoma. Curr Treat Options Oncol. 2025 Apr; 26 (4):251-259 Epub 2025 Mar 12
    View PubMed
  5. Garayua-Cruz L, Broida SE, Robinson SI, Okuno SH, Ho TP, Siontis BL, Sherman CE, Goulding KA, Houdek MT. Outcomes of Scapular Osteosarcoma. Anticancer Res. 2025 Jan; 45 (1):219-223
    View PubMed
  6. Schuetze SM, Ballman KV, Heise R, Ganjoo KN, Davis EJ, George S, Burgess MA, Choy E, Shepard DR, Tinoco G, Hirbe A, Kelly CM, Attia S, Deshpande HA, Schwartz GK, Siontis BL, Riedel RF, von Mehren M, Kozlowski E, Chen HX, Astbury C, Rubin BP. A Single-Arm Phase 2 Trial of Trametinib in Patients with Locally Advanced or Metastatic Epithelioid Hemangioendothelioma. Clin Cancer Res. 2024 Oct 15; 30 (20):4584-4592
    View PubMed
  7. Sawma T, Sultan A, Abdulmoneim S, Grotz T, Rosen CB, Taner T, Heimbach JK, Warner SG, Siontis BL, Ho TP, Robinson SI, Thiels CA. Management and Long-Term Outcomes of Patients With Hepatic Epithelioid Hemangioendothelioma. J Surg Oncol. 2024 Oct; 130 (5):1062-1069 Epub 2024 Sept 24
    View PubMed
  8. Coombs RA, Jebastin Thangaiah J, Siontis BL, Robinson SI, Okuno SH, Houdek MT, Xu-Welliver M, Ho TP. Tolerability and Outcomes for Treatment of Older Myxoid Liposarcoma Population. Cancers (Basel). 2024 Sep 23; 16(18).
    View PubMed
  9. Broida SE, Arguello AM, Sullivan MH, Robinson SI, Okuno SH, Siontis BL, Ho TP, Rose PS, Xu-Welliver M, Houdek MT. Unplanned Excision of Synovial Sarcoma: Factors Associated with Recurrence and Survival. Cancers (Basel). 2024 Sep 14; 16(18).
    View PubMed
  10. Stergiopoulos GM, Siontis BL, Petersen IA, Houdek MT, Ho TP, Okuno SH, Robinson SI. Cardiac Metastasis from Myxoid Liposarcoma Managed Successfully with Chemotherapy and Radiotherapy: Case Report and Review of the Literature. Curr Oncol. 2024 Sep 12; 31 (9):5384-5398 Epub 2024 Sept 12
    View PubMed
  11. Garayua-Cruz L, Broida SE, Okuno SH, Robinson SI, Siontis BL, Welliver MX, Wilke BK, Goulding KA, Rose PS, Houdek MT. Outcomes of non-angiosarcoma radiation-associated soft tissue sarcomas of the chest. J Surg Oncol. 2024 Jul; 130 (1):56-63 Epub 2024 June 12
    View PubMed
  12. Kowalchuk RO, Mullikin TC, Spears GM, Johnson-Tesch BA, Rose PS, Siontis BL, Kun Kim D, Costello BA, Morris JM, Gao RW, Shiraishi S, Lucido JJ, Olivier KR, Owen D, Stish BJ, Waddle MR, Laack NN, Park SS, Brown PD, Merrell KW. Assessment of minimum target dose as a predictor of local failure after spine SBRT. Radiother Oncol. 2024 Jun; 195:110260 Epub 2024 Mar 27
    View PubMed
  13. Heinrich MC, Jones RL, George S, Gelderblom H, Schoffski P, von Mehren M, Zalcberg JR, Kang YK, Razak AA, Trent J, Attia S, Le Cesne A, Siontis BL, Goldstein D, Boye K, Sanchez C, Steeghs N, Rutkowski P, Druta M, Serrano C, Somaiah N, Chi P, Reichmann W, Sprott K, Achour H, Sherman ML, Ruiz-Soto R, Blay JY, Bauer S. Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial. Nat Med. 2024 Feb; 30 (2):498-506 Epub 2024 Jan 05
    View PubMed
  14. Wahlig BD, Broida SE, Rose PS, Robinson SI, Siontis BL, Houdek MT. Is Bone Marrow Aspiration and Biopsy of Clinical Importance in the Initial Staging of Extraskeletal Ewing Sarcoma? Clin Orthop Relat Res. 2023 Nov 1; 481 (11):2177-2182 Epub 2023 Apr 13
    View PubMed
  15. Gelderblom H, Jones RL, Blay JY, George S, von Mehren M, Zalcberg JR, Kang YK, Razak AA, Trent J, Attia S, Le Cesne A, Siontis BL, Goldstein D, Boye K, Sanchez C, Steeghs N, Rutkowski P, Druta M, Serrano C, Somaiah N, Chi P, Harrow B, Becker C, Reichmann W, Sherman ML, Ruiz-Soto R, Heinrich MC, Bauer S, INTRIGUE investigators. Patient-reported outcomes and tolerability in patients receiving ripretinib versus sunitinib after treatment with imatinib in INTRIGUE, a phase 3, open-label study. Eur J Cancer. 2023 Oct; 192:113245 Epub 2023 July 20
    View PubMed
  16. Degnim AC, Siontis BL, Ahmed SK, Hoskin TL, Hieken TJ, Jakub JW, Baum CL, Day C, Schrup SE, Smith L, Carter JM, Sae-Kho TM, Sae Kho TM, Glazebrook KN, Vijayasekaran A, Okuno SH, Petersen IA. Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast. Clin Cancer Res. 2023 Aug 1; 29 (15):2885-2893
    View PubMed
  17. Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS. Treatment outcomes of extraskeletal Ewing sarcoma. J Surg Oncol. 2023 Jul; 128 (1):105-110 Epub 2023 Mar 31
    View PubMed
  18. Ho TP, Dykhoff H, Sangaralingham LR, Siontis BL, Grotz TE, Okuno SH, Robinson SI. Disparities in tyrosine kinase inhibitor use in older patients with gastrointestinal stromal tumors. J Geriatr Oncol 2023 May; 14 (4):101441 Epub 2023 Jan 28
    View PubMed
  19. Hickman A, Siontis BL. Not All Leiomyosarcomas Are the Same: How to Best Classify LMS. Curr Treat Options Oncol. 2023 Apr; 24 (4):327-337 Epub 2023 Mar 08
    View PubMed
  20. Houdek MT, Mallett KE, Heidenreich MJ, Ahmed SK, Wenger DE, Smith JH, Siontis BL, Robinson SI, Folpe AL, Petersen IA, Rose PS. Lack of radiosensitivity predicts poor disease specific survival in myxoid liposarcoma. J Surg Oncol. 2023 Apr; 127 (5):848-854 Epub 2022 Dec 27
    View PubMed
  21. Heater NK, Okuno S, Robinson S, Attia S, Seetharam M, Siontis BL, Yoon J, Chawla S, Milhem MM, Monga V, Skubitz K, Charlson J, Hirbe AC, Weiss MC, Van Tine B, Agulnik M. The Midwest Sarcoma Trials Partnership: Bridging Academic and Community Networks in a Collaborative Approach to Sarcoma. J Clin Med. 2023 Mar 29; 12 (7)
    View PubMed
  22. Kowalchuk RO, Mullikin TC, Florez M, De BS, Spears GM, Rose PS, Siontis BL, Kim DK, Costello BA, Morris JM, Marion JT, Johnson-Tesch BA, Gao RW, Shiraishi S, Lucido JJ, Trifiletti DM, Olivier KR, Owen D, Stish BJ, Waddle MR, Laack NN, Park SS, Brown PD, Ghia AJ, Merrell KW. Development and validation of a recursive partitioning analysis-based pretreatment decision-making tool identifying ideal candidates for spine stereotactic body radiation therapy. Cancer. 2023 Mar 15; 129(6):956-965. Epub 2022 Dec 26.
    View PubMed
  23. Patel MH, Guerrero Vinsard D, Agrawal U, Kendziora RW, Siontis BL, Swaroop Vege S, Sweetser S. Primary Pancreatic Undifferentiated Pleomorphic Sarcoma. ACG Case Rep J. 2023 Mar; 10 (3):e01011 Epub 2023 Mar 22
    View PubMed
  24. Kowalchuk R, Mullikin TC, Breen W, Gits HC, Florez M, De B, Harmsen WS, Rose PS, Siontis BL, Costello BA, Morris JM, Lucido JJ, Olivier KR, Stish B, Laack NN, Park S, Owen D, Ghia AJ, Brown PD, Merrell KW. Development and validation of a unifying pre-treatment decision tool for intracranial and extracranial metastasis-directed radiotherapy. Front Oncol. 2023; 13:1095170 Epub 2023 Mar 27
    View PubMed
  25. Kowalchuk RO, Johnson-Tesch BA, Marion JT, Mullikin TC, Harmsen WS, Rose PS, Siontis BL, Kim DK, Costello BA, Morris JM, Gao RW, Shiraishi S, Lucido JJ, Sio TT, Trifiletti DM, Olivier KR, Owen D, Stish BJ, Waddle MR, Laack NN, Park SS, Brown PD, Merrell KW. Development and Assessment of a Predictive Score for Vertebral Compression Fracture After Stereotactic Body Radiation Therapy for Spinal Metastases. JAMA Oncol. 2022 Mar 01; 8(3):412-419.
    View PubMed
  26. Kowalchuk RO, Mullikin TC, Harmsen WS, Rose PS, Siontis BL, Kim DK, Costello BA, Morris JM, Marion JT, Johnson-Tesch BA, Gao RW, Shiraishi S, Lucido JJ, Olivier KR, Owen D, Stish BJ, Laack NN, Park SS, Brown PD, Merrell KW. Development and Internal Validation of a Recursive Partitioning Analysis-Based Model Predictive of Pain Flare Incidence After Spine Stereotactic Body Radiation Therapy. Pract Radiat Oncol. 2022 Jul-Aug; 12(4):e269-e277. Epub 2022 Feb 10.
    View PubMed
  27. Lucido JJ, Mullikin TC, Abraha F, Harmsen WS, Vaishnav BD, Brinkmann DH, Kowalchuk RO, Marion JT, Johnson-Tesch BA, El Sherif O, Brown PD, Rose PS, Owen D, Morris JM, Waddle MR, Siontis BL, Stish BJ, Pafundi DH, Laack NN, Olivier KR, Park SS, Merrell KW. Single and Multifraction Spine Stereotactic Body Radiation Therapy and the Risk of Radiation Induced Myelopathy. Adv Radiat Oncol. 2022 Nov-Dec; 7(6):101047. Epub 2022 Aug 13.
    View PubMed
  28. Siontis BL, McHugh JB, Roberts E, Zhao L, Thomas DG, Owen D, Baker LH, Biermann JS, Schuetze SM, Chugh R. Differential Outcomes and Biologic Markers of Radiation-Associated vs. Sporadic Osteosarcoma: A Single-Institution Experience. Front Oncol. 2019; 9:1523 Epub 2020 Jan 22
    View PubMed
  29. Siontis BL, Leja M, Chugh R. Current clinical management of primary cardiac sarcoma. Expert Rev Anticancer Ther. 2020 Jan; 20 (1):45-51 Epub 2020 Jan 09
    View PubMed
  30. Waters R, Horvai A, Greipp P, John I, Demicco EG, Dickson BC, Tanas MR, Larsen BT, Ud Din N, Creytens DH, Bahrami A, Doyle LA, Jo VY, Al-Ibraheemi A, Thway K, Jenkins SM, Siontis B, Folpe A, Fritchie K. Atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma in patients aged View PubMed
  31. Anna Maria Frezza MD, Tarek Assi MD, Salvatore Lo Vullo, Eytan Ben-Ami MD, Armelle Dufresne MD, Kan Yonemori MD, Emi Noguchi MD, Brittany Siontis MD, Richard Ferraro MD, Pawel Teterycz MD, Florence Duffaud MD, Vinod Ravi MD, Bruno Vincenzi MD. Systemic treatments in MDM2 positive intimal sarcoma: A multicentre experience with anthracycline, gemcitabine, and pazopanib within the World Sarcoma Network Cancer. 2019; 126(1):98-104.
  32. Siontis BL, Zhao L, Leja M, McHugh JB, Shango MM, Baker LH, Schuetze SM, Chugh R. Primary Cardiac Sarcoma: A Rare, Aggressive Malignancy with a High Propensity for Brain Metastases. Sarcoma. 2019; 2019:1960593 Epub 2019 Mar 10
    View PubMed
  33. Siontis BL, Chugh R, Schuetze S. The potential of emerging therapeutics for epithelioid sarcoma. Expert Opinion on Orphan Drugs. 2018; 5(12):983-9.
  34. Clay RD, Iyer VN, Reddy DR, Siontis B, Scanlon PD. The "Complex Restrictive" Pulmonary Function Pattern: Clinical and Radiologic Analysis of a Common but Previously Undescribed Restrictive Pattern. Chest. 2017 Dec; 152 (6):1258-1265 Epub 2017 July 17
    View PubMed
  35. Mazur M, Wang F, Hodge DO, Siontis BL, Beinborn DS, Villarraga HR, Lerman A, Friedman PA, Herrmann J. Burden of Cardiac Arrhythmias in Patients With Anthracycline-Related Cardiomyopathy. JACC Clin Electrophysiol. 2017 Feb; 3 (2):139-150 Epub 2016 Sept 28
    View PubMed
  36. Siontis B, Kumar S, Dispenzierei A, Drake MT, Lacy MQ, Budadi F, Dingli D, Kapoor P, Gonsalves W, Gertz MA, Rajkumar SV. Positron emission tomography-computed tomography in the diagnostic evaluation of smoldering multiple myeloma: identification of patients needing therapy. Blood Cancer J. 2015 Dec 24; 5(e364).
  37. Ramar K, Siontis BL. In Reply – Early goal directed therapy for severe sepsis. Mayo Clinic Proceedings. 2015; 90(4):557-8.
  38. Siontis B, Elmer J, Dannielson R, Brown C, Park J, Surani S, Ramar K. Multifaceted interventions to decrease mortality in patients with severe sepsis/septic shock-a quality improvement project. PeerJ. 2015; 3:e1290 Epub 2015 Oct 20
    View PubMed
  39. Dykstra BL, Ramar K. Meningococcemia and Purpura Fulminans. Mayo Clinic Proceedings. 2014; 89(12):1718-21.
  40. Dykstra BL, Ramar K. 19-year-old woman with multiorgan failure and purpura. Mayo Clin Proc. 2014 Dec; 89(12):1718-21.
    View PubMed
PST-20461844