The Department of Urology at Mayo Clinic has long been at the forefront of research on partial nephrectomy, also called kidney-sparing surgery. Mayo Clinic studies suggest that:
- People with kidney cancers smaller than 1.5 inches (about 4 centimeters) have a significantly higher 10-year survival rate compared with those who had their entire kidney removed.
- In more-advanced stages of local cancers, outcomes and survival rates appeared similar for people whether they had a partial nephrectomy or a radical nephrectomy.
- Restriction of the blood supply (ischemia) has little effect on long-term kidney function after partial nephrectomy.
- Experienced surgeons can achieve good outcomes with minimally invasive partial and radical nephrectomies, reducing the need for open surgery.
Survival rates also appear to relate to surgical training, experience and expertise.
See a list of publications by Mayo doctors on nephrectomy and partial nephrectomy on PubMed, a service of the National Library of Medicine.
May 16, 2015
- Nephrectomy. National Kidney Foundation. https://www.kidney.org/atoz/content/nephrectomy. Accessed April 15, 2015.
- Renal cell carcinoma. The Merck Manual Professional Edition. http://www.merckmanuals.com/professional/genitourinary-disorders/genitourinary-cancer/renal-cell-carcinoma. Accessed April 20, 2015.
- Wilms' tumor. The Merck Manual Professional Edition. http://www.merckmanuals.com/professional/pediatrics/pediatric-cancers/wilms-tumor. Accessed April 20, 2015.
- Wein AJ, et al., eds. Contemporary open surgery of the kidney. In: Campbell-Walsh Urology. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed April 16, 2015.
- Wein AJ, et al., eds. Laparoscopic surgery of the kidney. In: Campbell-Walsh Urology. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed April 16, 2015.
- Solitary kidney. National Kidney and Urologic Diseases Information Clearinghouse. http://kidney.niddk.nih.gov/kudiseases/pubs/solitarykidney. Accessed April 15, 2015.
- Richie JP. Definitive surgical management of renal cell carcinoma. http://www.uptodate.com/home. Accessed April 22, 2015.
- Ramos E, et al. Evaluation of the living kidney donor and risk of donor nephrectomy. http://www.uptodate.com/home. Accessed April 22, 2015.
- AskMayoExpert. Donor nephrectomy living kidney donor. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- AskMayoExpert. Partial nephrectomy. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Shapiro R, et al. Benefits and complications of laparoscopic donor nephrectomy. http://www.uptodate.com/home. Accessed April 22, 2015.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. Jan. 13, 2015.
- Leach GE, et al. Partial nephrectomy: Mayo Clinic experience 1957-1977. Urology. 1980;15:219.
- Thompson RH, et al. Radical nephrectomy for pT1a renal masses may be associated with decreased overall survival compared with partial nephrectomy. The Journal of Urology. 2008;179:468.
- Breau RH, et al. Outcome of stage T2 or greater renal cell cancer treated with partial nephrectomy. The Journal of Urology. 2010;183:903.
- Thompson RH, et al. Partial versus radical nephrectomy for 4 to 7 cm renal cortical tumors. The Journal of Urology. 2009;182:2601.
- Tan HJ, et al. Long-term survival following partial vs. radical nephrectomy among older patients with early-stage kidney cancer. Journal of the American Medical Association. 2012;307:1629.
- Castle EP (expert opinion). Mayo Clinic, Phoenix, Ariz. May 1, 2015.
- Salevitz DA, et al. The impact of ischemia on long-term renal function after partial nephrectomy in the two kidney model. Journal of Endourology. 2015;29:474.
- Wisenbaugh ES, et al. Massive renal size is not a contraindication to a laparoscopic approach for bilateral native nephrectomies in autosomal dominant polycystic kidney disease (ADPKD). BJU International. 2015;115:796.