Neutropenia may be caused by:

  • Cancer or other diseases that damage bone marrow
  • Congenital disorders characterized by poor bone marrow function
  • Viral infections that disrupt bone marrow function
  • Autoimmune disorders that destroy neutrophils or bone marrow cells
  • Overwhelming infections that use up neutrophils faster than they can be produced
  • Drugs that destroy neutrophils or damage bone marrow

Possible causes of neutropenia include:

  1. Alcohol use disorder or chronic alcohol use
  2. Aplastic anemia
  3. Chemotherapy
  4. Chronic idiopathic neutropenia in adults
  5. Drugs, such as antibiotics and diuretics
  6. Hepatitis A
  7. Hepatitis B
  8. Hepatitis C
  10. Hypersplenism, a premature destruction of blood cells by the spleen
  11. Hyperthyroidism (overactive thyroid)
  12. Kostmann's syndrome, a congenital disorder involving low neutrophil production
  13. Leukemia
  14. Lupus
  15. Lyme disease
  16. Malaria
  17. Myelodysplastic syndromes
  18. Myelofibrosis
  19. Myelokathexis, a congenital disorder involving failure of neutrophils to enter the bloodstream
  20. Other autoimmune disorders
  21. Other congenital disorders
  22. Other infectious diseases
  23. Other parasitic diseases
  24. Radiation therapy
  25. Rheumatoid arthritis
  26. Salmonella infection
  27. Sepsis
  28. Syndrome-associated neutropenia
  29. Vitamin deficiencies

Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis.

Jan. 24, 2013