High blood protein is an increase in the concentration of protein in the bloodstream. The medical term for high blood protein is hyperproteinemia. High blood protein is not a specific disease or condition, but it might indicate you have a disease.
High blood protein rarely causes symptoms on its own. But sometimes it is uncovered while you're having blood tests done for a separate issue or symptom.
If your health care provider discovers high blood protein during an evaluation, additional tests can help determine if there is an underlying problem.
A total protein test can determine whether you have high blood protein. Other more-specific tests, including serum protein electrophoresis (SPEP), can help determine the exact source, such as liver or bone marrow. These tests also can identify the specific protein type involved in your high blood protein levels. Your provider may order an SPEP if a bone marrow disease is suspected.
Show References
- Total protein and albumin/globulin (A/G) ratio. American Association for Clinical Chemistry. https://www.testing.com/tests/total-protein-albumin-globulin-ag-ratio/. Accessed Oct. 28, 2022.
- Amyloidosis and kidney disease. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/kidney-disease/amyloidosis. Accessed Oct. 28, 2022.
- Monoclonal gammopathies of undetermined significance (MGUS). Merck Manual Professional Version. https://www.merckmanuals.com/professional/hematology-and-oncology/plasma-cell-disorders/monoclonal-gammopathy-of-undetermined-significance-mgus. Accessed Oct. 28, 2022.
- Laubach JP. Diagnosis of monoclonal gammopathy of undetermined significance. https://www.uptodate.com/contents/search. Accessed Oct. 28, 2022.
- Blood basics. American Society of Hematology. https://www.hematology.org/education/patients/blood-basics. Accessed Oct. 28, 2022.
Original article: https://www.mayoclinic.org/symptoms/high-blood-protein/basics/causes/SYM-20050599