Overview

Cortisone shots are injections that can help relieve pain, swelling and irritation in a specific area of your body. They're most often injected into joints such as the ankle, elbow, hip, knee, shoulder, spine or wrist. Even the small joints in the hands or feet might benefit from cortisone shots.

A cortisone shot usually contains a corticosteroid medicine for pain relief over time and a local anesthetic to numb the pain right away.

Often, you can receive a cortisone shot at your healthcare professional's office. Because of potential side effects, the number of shots given in a year generally is limited.

Why it's done

Cortisone shots might be most effective in treating inflammatory arthritis, such as rheumatoid arthritis. They also can be part of treatment for other conditions, including:

  • Back pain.
  • Bursitis.
  • Gout.
  • Osteoarthritis.
  • Psoriatic arthritis.
  • Rheumatoid arthritis.
  • Tendinitis.

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Risks

Potential side effects of cortisone shots increase with larger doses and more frequent use.

Side effects can include:

  • Cartilage damage.
  • Death of nearby bone.
  • Joint infection.
  • Nerve damage.
  • Short-term facial flushing.
  • Short-term flare of pain, swelling and irritation in the joint.
  • Short-term increase in blood sugar.
  • Tendon weakening or rupture.
  • Thinning of nearby bone, called osteoporosis.
  • Thinning of skin and soft tissue around the injection site.
  • Whitening or lightening of the skin around the injection site.

Limits on the number of cortisone shots

There's concern that repeated cortisone shots might damage the cartilage within a joint. So healthcare professionals typically limit the number of cortisone shots into a joint. The number can depend on the joint, the diagnosis and other factors.

How you prepare

If you take blood thinners, you might need to stop taking them for a few days before the cortisone shot. This reduces the risk of bleeding or bruising. Some dietary supplements also have a blood-thinning effect. Ask your care team what medicines and supplements to avoid before a cortisone shot.

Tell your care team if you've had a temperature of 100.4 degrees Fahrenheit (38 degrees Celsius) or greater in the previous two weeks.

What you can expect

During the cortisone shot

Your healthcare professional might ask you to change into a gown. You'll then be positioned so that the needle can be inserted easily into the joint.

The area around the injection site is cleaned. The care team also might spray a medicine that numbs an area where the needle will be inserted. In some cases, the healthcare professional uses an ultrasound or a type of X-ray called fluoroscopy to see the needle's progress inside the body. This helps with placing the needle in the right spot.

You'll likely feel some pressure when the needle is inserted. Let your care team know if you have a lot of discomfort.

The medicine is then released into the injection site. Typically, cortisone shots include a corticosteroid medicine to relieve pain, swelling and irritation over time plus a numbing medicine to provide pain relief right away.

After the cortisone shot

Some people have a change in skin color and feeling of warmth of the chest and face after a cortisone shot. If you have diabetes, a cortisone shot might temporarily increase your blood sugar levels.

After a cortisone shot, your care team might ask that you:

  • Protect the affected area for a day or two. For instance, if you received a cortisone shot in your shoulder, avoid heavy lifting. If you received a cortisone shot in your knee, stay off your feet when you can.
  • Use ice on the injection site as needed to relieve pain. Don't use heating pads.
  • Do not use a bathtub, hot tub or whirlpool for two days. It's OK to shower.
  • Watch for signs of infection, including increasing pain, skin color changes and swelling lasting more than 48 hours.

Results

Results of cortisone shots often depend on the reason for the treatment. Cortisone shots commonly cause a short-term flare in pain, swelling and irritation for up to two days after the injection. After that, the pain, swelling and irritation should generally lessen. The pain relief can last up to several months.

March 24, 2026
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Cortisone shots