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Mayo Clinic physicians treat non-Hodgkin lymphoma using multidisciplinary teams that collaborate to develop the most appropriate treatment plan for each patient. Patients with non-Hodgkin lymphoma have access to the Mayo Clinic Cancer Center. The National Cancer Institute designated Mayo Clinic Cancer Center a comprehensive cancer center in recognition of its extensive, innovative capabilities.
Mayo Clinic specialists use advanced diagnostic tests and procedures, including blood tests, biopsies, X-rays, and computed tomography (CT) and positron emission tomography (PET) scans. Read more about non-Hodgkin lymphoma diagnosis.
Physicians from multiple Mayo Clinic departments collaborate to provide innovative care to each patient regardless of the form of non-Hodgkin lymphoma. Specialists may use chemotherapy, radiation therapy, stem cell transplantation or a combination of these therapies depending on the patient's needs. If the lymphoma is a slow-growing type, physicians may take a wait-and-see approach with regularly scheduled observations. If the lymphoma is aggressive, combination therapy may be necessary. Read more about non-Hodgkin lymphoma treatment options.
Like other kinds of lymphoma, non-Hodgkin lymphoma begins in a patient's lymphocytes (lymph cells), either B cells or T cells. A lymphocyte that grows abnormally and becomes a cancer cell fails to protect the body against disease, but rather begins to accumulate in lymph nodes and other organs. At least 30 forms of non-Hodgkin lymphoma have been identified. About 95 percent of non-Hodgkin lymphomas are diagnosed in adults, and about 5 percent in children.
The most common type of non-Hodgkin lymphoma is diffuse large B-cell lymphoma, which accounts for about a third of the cases in the United States. About one-fourth of non-Hodgkin lymphomas involve one of two related diseases, chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). Other forms include follicular lymphoma, various marginal zone lymphomas, and several kinds of peripheral T-cell lymphomas. Forms that each account for a tiny percentage of all lymphomas include mantle-cell lymphoma, primary mediastinal B-cell lymphoma, Burkitt lymphoma, and lymphoplasmocytic lymphoma.
In children, the most common types are lymphoblastic lymphoma, small noncleaved cell lymphoma (which may be Burkitt or non-Burkitt lymphoma), and large cell lymphoma.
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