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The GALAD model is a statistical model for estimating the likelihood of hepatocellular carcinoma (HCC) in patients with chronic liver disease.
This calculator is intended for use by health care providers. The results of this tool should never be used alone to determine a patient's medical treatment. This tool is a statistical model and is not a substitute for an individual treatment plan developed by a doctor with personal knowledge of a specific patient. Other important factors that must be considered include the patient's own medical history and the experience, knowledge and training of the doctor. Doctors should personally discuss these results with patients when presenting prognoses or treatment recommendations.
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This probability estimate is dependent on the prevalence of the disease (HCC) within the specific population.
The GALAD model was developed in a cohort where 49% of the population had HCC.
According to Mayo Clinic internal data, a GALAD score of 1.17 is a cutoff providing 98% specificity and 63% sensitivity.
Des-gamma-carboxy prothrombin (DCP)
The GALAD model was developed using data from 670 patients (331 with HCC and 339 with chronic liver disease) from a single UK center and has been validated in independent cohorts of 6834 patients (2430 with HCC and 4404 with chronic liver disease) recruited from Germany, Japan, and Hong Kong.
Performance of the GALAD score varies by etiology of HCC and therefore differs in different regions of the world.
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