Your spleen is an organ located just below your left rib cage. Many conditions — including infections, liver disease and some cancers — can cause an enlarged spleen, also known as splenomegaly (spleh-no-MEG-uh-lee).
An enlarged spleen usually doesn't cause symptoms. It's often discovered during a routine physical exam. Your doctor generally can't feel a normal-sized spleen in adults but can feel an enlarged spleen. Your doctor will likely request imaging and blood tests to help identify the cause.
Treatment for an enlarged spleen focuses on the underlying condition that's causing it. Surgically removing an enlarged spleen isn't usually the first treatment, but is sometimes recommended.