Estradiol And Dienogest (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Breast pain, discomfort, or tenderness
2. headache, severe and throbbing
3. irregular menstrual periods
4. nausea
5. normal menstrual bleeding occurring earlier, possibly lasting longer than expected
6. vomiting

Rare

1. Abdominal or stomach pain
2. chills
3. clay-colored stools
4. dark urine
5. difficulty with breathing
6. dizziness
7. fever
8. headache
9. itching
10. loss of appetite
11. pain in the chest, groin, or legs, especially the calves
12. rash
13. slurred speech
14. sudden loss of coordination
15. sudden, severe weakness or numbness in the arm or leg
16. sudden, unexplained shortness of breath
17. unpleasant breath odor
18. unusual tiredness or weakness
19. vision changes
20. vomiting of blood
21. yellow eyes or skin

Incidence not known

1. Abdominal or stomach bloating
2. anxiety
3. blood in the stool
4. chest pain or discomfort
5. decrease in the amount of urine
6. fainting
7. hives
8. irritation
9. itching of the vagina or genitals
10. joint pain, stiffness, or swelling
11. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
12. noisy, rattling breathing
13. pain in the ankles or knees
14. pain or discomfort in the arms, jaw, back, or neck
15. pain, redness, or swelling in the arm or leg
16. painful, red lumps under the skin, mostly on the legs
17. pelvic pain
18. pounding in the ears
19. redness of the skin
20. shortness of breath
21. slow or fast heartbeat
22. stomach or pelvic discomfort, aching, or heaviness
23. sweating
24. swelling of the eyelids, face, lips, hands, lower legs, or feet
25. thick, white vaginal discharge with mild or no odor
26. tightness in the chest
27. troubled breathing at rest
28. troubled breathing or swallowing
29. upper right abdominal or stomach pain
30. weight gain
31. wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

1. Blemishes on the skin
2. increased weight
3. pimples

Incidence not known

1. Patchy brown or dark brown discoloration of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: June 01, 2024

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