More than 40 percent of patients taking opioids for chronic noncancer pain experience severe constipation. Most fail to respond fully to conventional laxative therapy, but an emerging class of peripherally restricted opioid receptor antagonists may provide better response rates.

The number of diagnosed pancreatic cysts has increased significantly in the last decade. Although the overall risk of malignancy is low, it's still not clear which cysts require additional analysis, resection or follow-up.

The incidence of eosinophilic esophagitis (EoE) is increasing in children and adolescents. Mayo Clinic recently initiated a dedicated, multispecialty EoE clinic to bring more-focused, individualized care to young patients.

Increased intestinal permeability has a pathogenic role in celiac disease, IBS and non-celiac gluten sensitivity. Now, two clinical trials are using probe-based confocal laser endomicroscopy to further investigate the relationship between gut barrier function, IBS and gluten.

Biologic drug monitoring may improve outcomes in IBD patients
Measuring TPMT genotypes or enzyme activity is an established and cost-effective method for individualizing dosing of thiopurines. Studies suggest that monitoring anti-TNF drug concentrations and antibodies may provide similar benefits for patients treated with biologics.

See all Gastroenterology and Hepatology Clinical Trials at Mayo Clinic

Dec. 5-6, 2014, in Phoenix
This course offers a comprehensive approach to advances in esophageal disease, including high-resolution manometry and impedance monitoring, new techniques in endoscopic detection and treatment of Barrett's esophagus, and insights into eosinophilic esophagitis.

Feb. 23-27, 2015, in Maui, Hawaii
This course covers a wide range of topics in gastroenterology, hepatology and endoscopy, including inflammatory bowel disease, colorectal neoplasia and pancreaticobiliary disorders.

See all Gastroenterology Continuous Professional Development courses

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