Proper Use

Drug information provided by: Micromedex

Take this medicine exactly as directed by your doctor. Do not take more or less of it and do not take it more often than your doctor ordered. Using too much will increase the chance for side effects, while using too little may cause you to reject your transplanted organ.

This medicine comes with a patient information insert. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

This medicine is always used together with other medicines. Make sure you understand when to take all of your medicines during the day. Your doctor will give you a daily plan for taking your medicines.

You may take the immediate-release capsule with or without food. But take it the same way each time.

If you are using the extended-release capsule:

  • Swallow the capsule whole with liquid. Do not crush, break, chew, or divide it.
  • Take the capsule every morning, preferably on an empty stomach at least 1 hour before or at least 2 hours after breakfast.
  • Do not drink alcohol with the capsule.

You should not eat grapefruit or drink grapefruit juice while you are taking this medicine. Grapefruit and grapefruit juice will increase the amount of medicine in the body.

Do not stop taking this medicine without first checking with your doctor. You might have to take medicine for the rest of your life to prevent your body from rejecting the transplant.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release capsules):
    • To prevent kidney transplant rejection:
      • Adults and children 16 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually between 0.1 to 0.2 milligram (mg) per kilogram (kg) of body weight per day given as a single dose. Your doctor may adjust the dose as needed.
      • Children younger than 16 years of age—Use and dose must be determined by your doctor.
  • For oral dosage form (capsules):
    • To prevent heart transplant rejection:
      • Adults—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 0.075 milligram (mg) per kilogram (kg) of body weight per day, divided into two doses and taken every 12 hours. Your doctor may adjust the dose as needed.
      • Children—Use and dose must be determined by your doctor.
    • To prevent kidney transplant rejection:
      • Adults—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 0.1 to 0.2 milligram (mg) per kilogram (kg) of body weight per day, divided into two doses and taken every 12 hours. Your doctor may adjust the dose as needed.
      • Children—Use and dose must be determined by your doctor.
    • To prevent liver transplant rejection:
      • Adults and teenagers 16 years of age and older—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 0.1 to 0.15 milligram (mg) per kilogram (kg) of body weight per day, divided into two doses and taken every 12 hours. Your doctor may adjust the dose as needed.
      • Teenagers and children younger than 16 years of age—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 0.15 to 0.2 mg per kg of body weight per day, divided into two doses and taken every 12 hours. Your doctor may adjust the dose as needed.

Missed Dose

If you miss a dose of Astagraf XL™ and it is less than 14 hours since the regular time, take the missed dose right away. If more than 14 hours have passed since the regular time, skip the dose and return to your regular schedule on the next day.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.