Side Effects

Drug information provided by: Micromedex

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Bleeding gums
  2. bloating or swelling of the face, arms, hands, fingers, lower legs, or feet
  3. blurred vision
  4. chest pain
  5. chills
  6. confusion
  7. coughing up blood
  8. cracked lips
  9. decreased urination
  10. decreased urine output
  11. diarrhea
  12. difficulty with breathing or swallowing
  13. dilated neck veins
  14. dizziness
  15. dry mouth
  16. extreme fatigue
  17. fainting
  18. fast, slow, or irregular heartbeat
  19. fever
  20. headache
  21. increase in heart rate
  22. increased menstrual flow or vaginal bleeding
  23. irregular breathing
  24. labored breathing
  25. lightheadedness
  26. nervousness
  27. nosebleeds
  28. paralysis
  29. pounding in the ears
  30. prolonged bleeding from cuts
  31. rapid breathing
  32. rapid weight gain
  33. red or black, tarry stools
  34. red or dark brown urine
  35. shortness of breath
  36. sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  37. sunken eyes
  38. swelling or inflammation of the mouth
  39. thirst
  40. tightness in the chest
  41. tingling of the hands or feet
  42. troubled breathing
  43. unusual tiredness or weakness
  44. unusual weight gain or loss
  45. wheezing
  46. wrinkled skin
  47. yellow eyes or skin

Less common

  1. Bleeding from the rectum
  2. bleeding from wounds
  3. constipation
  4. depressed mood
  5. dry skin and hair
  6. feeling cold
  7. hair loss
  8. hoarseness or husky voice
  9. indigestion
  10. loss of appetite
  11. muscle cramps and stiffness
  12. nausea
  13. pain in the chest, groin, or legs, especially the calves
  14. pain in the stomach, side, or abdomen, possibly radiating to the back
  15. severe stomach pain
  16. severe, sudden headache
  17. slurred speech
  18. sudden loss of coordination
  19. sudden, severe weakness or numbness in the arm or leg
  20. sudden, unexplained shortness of breath
  21. vision changes
  22. vomiting
  23. vomiting of blood or material that looks like coffee grounds


  1. Back pain
  2. chest discomfort
  3. cloudy or bloody urine
  4. convulsions
  5. darkening of the skin
  6. drowsiness
  7. general feeling of tiredness or weakness
  8. irregular or slow heart rate
  9. light-colored stools
  10. mental depression
  11. skin rash
  12. stomach pain, continuing

Incidence not known

  1. Cough
  2. coughing up blood
  3. dark-colored urine
  4. heavy jaw feeling
  5. increased thirst
  6. joint pain, stiffness, or swelling
  7. loosening of a tooth
  8. lower back or side pain
  9. muscle cramps or spasms
  10. muscular pain, tenderness, wasting, or weakness
  11. pain, swelling, or numbness in the mouth or jaw
  12. painful or difficult urination
  13. pale skin
  14. sore throat
  15. sudden, severe chest pain
  16. unusual bleeding or bruising
  17. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. belching
  3. blistering, peeling, redness, or swelling of the palms, hands, or bottoms of the feet
  4. change in color of the treated skin
  5. change in taste
  6. difficulty with moving
  7. discouragement
  8. excess air or gas in the stomach or intestines
  9. feeling sad or empty
  10. full feeling
  11. hair color changes
  12. hair loss or thinning of the hair
  13. heartburn
  14. irritability
  15. joint pain
  16. lack of appetite
  17. lack or loss of strength
  18. loss of interest or pleasure
  19. muscle aches or pains
  20. numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet
  21. pain or burning in the throat
  22. passing gas
  23. sleeplessness
  24. stomach discomfort, upset, or pain
  25. swollen joints
  26. trouble concentrating
  27. trouble sleeping
  28. unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.