Before Using

Drug information provided by: Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of streptokinase in the pediatric population. Safety and efficacy have not been established .

Geriatric

No information is available on the relationship of age to the effects of streptokinase in geriatric patients .

Pregnancy

Information about this streptokinase-intravenous-route-intracoronary-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Alteplase, Recombinant
  • Anistreplase
  • Apixaban
  • Ardeparin
  • Argatroban
  • Bivalirudin
  • Certoparin
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Dipyridamole
  • Enoxaparin
  • Fondaparinux
  • Heparin Sodium
  • Lepirudin
  • Nadroparin
  • Parnaparin
  • Pentosan Polysulfate Sodium
  • Phenindione
  • Phenprocoumon
  • Protein C, Human
  • Reteplase, Recombinant
  • Reviparin
  • Rivaroxaban
  • Streptokinase
  • Tenecteplase
  • Tinzaparin
  • Urokinase
  • Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aspirin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems or a history of bleeding in any part of the body or
  • Blood clotting disorder, uncontrolled or
  • Brain disease or tumor or
  • High blood pressure, uncontrolled or
  • Stroke, recent (within two months) or
  • Surgery or injury to the brain or spine, recent (within two months)—This medicine should NOT be used in these conditions .
  • Catheter (tube) infection or
  • Diabetes mellitus, uncontrolled or
  • Eye problems from diabetes (e.g., hemorrhagic retinopathy) or high blood pressure or
  • Heart disease or infections (e.g., mitral stenosis or endocarditis) or
  • Injections into a blood vessel or
  • Kidney disease, severe or
  • Liver disease, severe or
  • Lung disease (e.g., tuberculosis or severe bronchitis) or
  • Pancreatitis or
  • Placement of any tube into the body or
  • Surgery or injury of any kind, major and recent—The chance of serious bleeding may be increased .
  • Heart rhythm problems or
  • Hypotension—These conditions may get worse .
  • Streptococcal infection, recent (within 6 months) (e.g., sore throat, rheumatic fever)—This medicine may not be effective .