Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (18 years and older):

To treat attention-deficit hyperactivity disorder (ADHD), 400-milligram tablets of SAMe have been taken by mouth three times daily and then increased to a maximum of 800 milligrams three times daily for four weeks.

To treat bile flow problems, 1,600 milligrams of SAMe has been taken by mouth daily for two weeks. A dose of 1,000 milligrams has been injected into the vein (IV) daily for four weeks.

To treat bile flow problems in pregnancy, 500 milligrams of Transmetil® has been given by slow infusion twice daily for 14 days, followed by 500 milligrams of SAMe taken by mouth twice daily until or after delivery. A dose of 600 milligrams of Samyr® has been taken by mouth alone. A dose of 1,800 milligrams of Samyr® has been taken by mouth together with beta-mimetics daily. A dose of 500 milligrams has been taken by mouth twice daily. Doses of SAMe that have been given include: 1,000 milligrams injected into the muscle daily until delivery, 200 or 800 milligrams given through IV daily for 20 days; 800 milligrams given through IV daily in two divided doses until delivery; 800 milligrams given through IV; and 800 milligrams given through IV over three hours for 20 days. A dose of 800 milligrams of disulfate-p-toluene sulfonate stable salt (BioResearch, S.p.A, Milan, Italy) has been given through IV daily.

To treat depression, daily doses of 800-1,600 milligrams of SAMe by mouth for up to six weeks are most common. Daily doses of 200-1,600 milligrams have been taken by mouth or given through tube feeding. Doses of SAMe have been given through IV or injected into the muscle, ranging from 200 to 400 milligrams daily for up to eight weeks. A dose of 200 milligrams of SAMe has been taken by mouth twice daily for two days, followed by 1,000 milligrams daily for nine days, followed by 1,200 milligrams daily for nine days, followed by 1,600 milligrams daily to day 42. Doses of 1,000-1,600 milligrams have been taken by mouth daily for 15 days to six weeks. Doses of 150-400 milligrams given through IV daily for 3-4 weeks are most common. A dose of 400 milligrams of s-adenosyl-L-methionine 1,4-butanedisulphonate stable salt (Knoll Farmaceutici S.p.A., Liscate, Milan, Italy) has been injected into the muscle daily. Doses of 75-200 milligrams of SAMe have been injected into the muscle for 14-30 days. Doses of 200-400 milligrams of SAMe per 250 milliliters of saline have been given ithrough IV during the first three days of treatment, followed by 400 milligrams of SAMe daily on days 4-14. Doses of 45 milligrams or 150 milligrams of SAMe have been injected into the muscle for 1-2 weeks. Bolus injections of 200 milligrams of SAMe have been given once daily in the morning for 14 days. Doses of 200-1,600 milligrams of SAMe daily have been taken by mouth or given with tube feeding. Doses of SAMe that have been given include 200-400 milligrams daily of injectable formulas or 800-1,600 milligrams taken by mouth daily with meals and typically in divided doses, for up to eight weeks. Doses of 200-800 milligrams of SAMe have been given through IV daily or every other day for 2-3 weeks. A dose of 200 milligrams of SAMe has been injected into the muscle daily for 3-4 weeks, as has 15 milligrams three times daily for 15 days, or 150 milligrams daily for 15 days. Doses of 800-1,600 milligrams of SAMe have been taken by mouth daily. Doses of 150-400 milligrams have been given through IV or injected into the muscle daily. A dose of 400 milligrams of SAMe has been injected into the muscle daily for 28 days.

To treat depression caused by opiate use, 400 milligrams of SAMe has been given through an IV for six days, followed by 1,000 milligrams of SAMe taken by mouth once daily for one day or 200 milligrams of SAMe injected into the muscle once daily and 400 milligrams SAMe taken by mouth twice daily for six days, followed by 400 milligrams of SAMe taken by mouth three times daily for one day, for a total of four weeks.

To treat fibromyalgia, 400 milligrams has been taken by mouth twice daily. A dose of 200 milligrams has been injected into the muscle daily, plus 200 milligrams taken by mouth twice daily. Doses of 200-400 milligrams have been given through IV daily. A dose of 200 milligrams has been injected into the muscle daily with 200 milligrams of SAMe taken by mouth twice daily.

To treat general liver disease, 400-1,200 milligrams of SAMe has been taken by mouth daily for up to 24 weeks. A dose of 200 milligrams of Samyr® has been taken by mouth twice daily for six months. Doses ranging from 1,200 to 1,500 milligrams daily have been taken by mouth for 1-24 months. A dose of 600 milligrams of SAMe in 250 milliliters of saline has been injected into the muscle for three days, followed by 400 milligrams of SAMe taken by mouth three times daily for an additional 30 days. Doses of 200-800 milligrams of SAMe have been used daily for up to 15 days. A dose of 100 milligrams of SAMe has been injected into the muscle daily for 30 days. A single dose containing 50 milligrams of SAMe, 50-100 milligrams of SAMe daily, or 15 milligrams of SAMe have been given through IV or injected into the muscle four times daily for 30 days. A dose of 200 milligrams of SAMe has been injected into the muscle daily for 30 days. Doses of 200-800 milligrams have been given through IV daily for 15-17 days. A dose of 800 milligrams of SAMe has been given through IV daily for 17 days. A dose of 800 milligrams has been given through IV, followed by 1,600 milligrams given through IV. A dose of 600 milligrams of SAMe in 250 milliliters of saline has been given through IV for three days, followed by 400 milligrams of SAMe by mouth three times daily for an additional 30 days.

To treat osteoarthritis, 600mg-1,200 milligrams of SAMe has been taken by mouth daily in 1-3 divided doses for 10-84 days. A five-milliliter bolus containing 400 milligrams of SAMe has been given through IV daily for five days, followed by 200 milligrams of SAMe taken by mouth three times daily for 23 days. SAMe has been taken by mouth for 3-12 weeks in doses ranging from 200 milligrams 3-6 times daily to 400 milligrams 2-6 times daily; in some cases, 400 milligrams of SAMe has been given through IV once daily for the first five days, followed by SAMe taken by mouth. A dose of 60 milligrams of SAMe has been injected into the muscle for 7-14 days. SAMe has typically been taken by mouth for 3-12 weeks in doses ranging from 200 milligrams 3-6 times daily to 400 milligrams 2-6 times daily; however, 400 milligrams of SAMe has been given through IV once daily for five days before switching to a formula taken by mouth.

To treat schizophrenia, 400 milligrams of SAMe has been taken by mouth daily for the first week in divided doses, followed by 800 milligrams of SAMe in divided doses daily for the next seven week.

To treat cirrhosis (liver disease in which there is bile duct inflammation), 50-100 milligrams of SAMe has been given through IV or injected into the muscle in 1-4 divided doses or as a single treatment for up to 30 days.

To treat fatty liver disease, 250 milligrams of SAMe has been given through a slow bolus drip every 12 hours for 30 days in 500 milliliters of five-percent levulose.

To treat hepatitis (swelling and inflammation of the liver), 200 milligrams of SAMe has been given through IV daily for 15 days, followed by SAMe injected into the muscle for 15 days. A dose of 500 milligrams of SAMe has been given through IV in 250 milliliters of glucose solution daily until recovery.

Children (younger than 18 years):

To treat hepatitis, 75 milligrams of SAMe has been taken by mouth daily for 35 days in children under 13 years of age. A dose of 150 milligrams of SAMe has been taken by mouth daily for 35 days in children over 13 years of age. A dose of 100 milligrams of SAMe has been given through IV daily for 15 days, followed by SAMe injected into the muscle for 15 days.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com