Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of rifampin, isoniazid, and pyrazinamide combination in children younger than 15 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rifampin, isoniazid, and pyrazinamide combination in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Artemether
  • Atazanavir
  • Bictegravir
  • Boceprevir
  • Cabotegravir
  • Cobicistat
  • Daclatasvir
  • Darunavir
  • Dasabuvir
  • Delamanid
  • Doravirine
  • Elbasvir
  • Elvitegravir
  • Fosamprenavir
  • Fostemsavir
  • Glecaprevir
  • Grazoprevir
  • Isavuconazonium Sulfate
  • Lenacapavir
  • Lopinavir
  • Lorlatinib
  • Lurasidone
  • Maraviroc
  • Mavacamten
  • Nelfinavir
  • Nirmatrelvir
  • Ombitasvir
  • Pacritinib
  • Paritaprevir
  • Pibrentasvir
  • Praziquantel
  • Ranolazine
  • Rilpivirine
  • Ritonavir
  • Saquinavir
  • Sofosbuvir
  • Telaprevir
  • Tenofovir Alafenamide
  • Tipranavir
  • Velpatasvir
  • Voriconazole
  • Voxilaprevir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abemaciclib
  • Abiraterone Acetate
  • Abrocitinib
  • Acalabrutinib
  • Acetaminophen
  • Adagrasib
  • Afatinib
  • Alfentanil
  • Alpelisib
  • Amifampridine
  • Amiodarone
  • Amlodipine
  • Amprenavir
  • Apixaban
  • Apremilast
  • Aprepitant
  • Aripiprazole
  • Atogepant
  • Atovaquone
  • Avacopan
  • Avapritinib
  • Avatrombopag
  • Axitinib
  • Bedaquiline
  • Belumosudil
  • Bendamustine
  • Benzhydrocodone
  • Berotralstat
  • Betrixaban
  • Bortezomib
  • Bosutinib
  • Brexpiprazole
  • Brigatinib
  • Brivaracetam
  • Buprenorphine
  • Bupropion
  • Cabozantinib
  • Cannabidiol
  • Capivasertib
  • Capmatinib
  • Carbamazepine
  • Cariprazine
  • Celecoxib
  • Ceritinib
  • Cholera Vaccine, Live
  • Clarithromycin
  • Clopidogrel
  • Clozapine
  • Cobimetinib
  • Codeine
  • Copanlisib
  • Crizotinib
  • Cyclosporine
  • Dabigatran Etexilate
  • Daprodustat
  • Daridorexant
  • Darolutamide
  • Dasatinib
  • Deferasirox
  • Deflazacort
  • Delavirdine
  • Desogestrel
  • Dexamethasone
  • Dienogest
  • Digoxin
  • Dihydrocodeine
  • Dolutegravir
  • Domperidone
  • Donepezil
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Dronedarone
  • Drospirenone
  • Duvelisib
  • Edoxaban
  • Efavirenz
  • Elacestrant
  • Elagolix
  • Elexacaftor
  • Eliglustat
  • Eluxadoline
  • Encorafenib
  • Entrectinib
  • Enzalutamide
  • Eravacycline
  • Erdafitinib
  • Erlotinib
  • Estetrol
  • Estradiol
  • Ethinyl Estradiol
  • Ethionamide
  • Ethynodiol
  • Etonogestrel
  • Etrasimod
  • Etravirine
  • Everolimus
  • Exemestane
  • Fedratinib
  • Fenfluramine
  • Fentanyl
  • Fexinidazole
  • Finerenone
  • Fosaprepitant
  • Fosnetupitant
  • Fosphenytoin
  • Fostamatinib
  • Fruquintinib
  • Futibatinib
  • Gefitinib
  • Gepirone
  • Gestodene
  • Gilteritinib
  • Glasdegib
  • Glimepiride
  • Halothane
  • Hemin
  • Hydrocodone
  • Hydroxychloroquine
  • Ibrexafungerp
  • Ibrutinib
  • Idelalisib
  • Ifosfamide
  • Imatinib
  • Indinavir
  • Infigratinib
  • Iptacopan
  • Irinotecan
  • Irinotecan Liposome
  • Isoniazid
  • Istradefylline
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ixabepilone
  • Ixazomib
  • Ketoconazole
  • Lamotrigine
  • Lapatinib
  • Larotrectinib
  • Ledipasvir
  • Lefamulin
  • Lemborexant
  • Leniolisib
  • Letermovir
  • Levodopa
  • Levoketoconazole
  • Levonorgestrel
  • Linagliptin
  • Lorcainide
  • Lumateperone
  • Lurbinectedin
  • Macimorelin
  • Macitentan
  • Manidipine
  • Maribavir
  • Medroxyprogesterone
  • Meperidine
  • Mestranol
  • Methadone
  • Methotrexate
  • Metoprolol
  • Midostaurin
  • Mifepristone
  • Mirtazapine
  • Mitapivat
  • Mobocertinib
  • Momelotinib
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Naloxegol
  • Neratinib
  • Netupitant
  • Nevirapine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nintedanib
  • Nirogacestat
  • Nomegestrol
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Olanzapine
  • Olaparib
  • Oliceridine
  • Olutasidenib
  • Omaveloxolone
  • Omeprazole
  • Osimertinib
  • Oxcarbazepine
  • Oxycodone
  • Ozanimod
  • Palbociclib
  • Paliperidone
  • Palovarotene
  • Panobinostat
  • Pazopanib
  • Pemigatinib
  • Pentazocine
  • Perampanel
  • Pexidartinib
  • Phenobarbital
  • Phenytoin
  • Pimavanserin
  • Piperaquine
  • Pirtobrutinib
  • Pitavastatin
  • Pitolisant
  • Ponatinib
  • Ponesimod
  • Posaconazole
  • Pralsetinib
  • Pretomanid
  • Primidone
  • Pyrazinamide
  • Quetiapine
  • Quinine
  • Quizartinib
  • Regorafenib
  • Relugolix
  • Repotrectinib
  • Revefenacin
  • Ribociclib
  • Rifampin
  • Rimegepant
  • Ripretinib
  • Risperidone
  • Ritlecitinib
  • Rivaroxaban
  • Roflumilast
  • Rolapitant
  • Romidepsin
  • Ruxolitinib
  • Samidorphan
  • Segesterone
  • Selexipag
  • Selpercatinib
  • Selumetinib
  • Sildenafil
  • Simeprevir
  • Siponimod
  • Sirolimus
  • Sirolimus Protein-Bound
  • Sonidegib
  • Sorafenib
  • Sotagliflozin
  • Sotorasib
  • Sparsentan
  • Stiripentol
  • Sufentanil
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Tasimelteon
  • Tazemetostat
  • Tegafur
  • Telithromycin
  • Temsirolimus
  • Tezacaftor
  • Thiotepa
  • Ticagrelor
  • Tivozanib
  • Tofacitinib
  • Tolvaptan
  • Trabectedin
  • Tramadol
  • Tucatinib
  • Ubrogepant
  • Ulipristal
  • Upadacitinib
  • Valbenazine
  • Vandetanib
  • Vemurafenib
  • Venetoclax
  • Vilazodone
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Voclosporin
  • Vonoprazan
  • Vorapaxar
  • Vortioxetine
  • Voxelotor
  • Zanubrutinib
  • Zavegepant
  • Zidovudine
  • Zolpidem
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetyldigoxin
  • Aliskiren
  • Aminosalicylic Acid
  • Anisindione
  • Aripiprazole Lauroxil
  • Atorvastatin
  • Betamethasone
  • Bexarotene
  • Bosentan
  • Buspirone
  • Carbamazepine
  • Carvedilol
  • Caspofungin
  • Chloramphenicol
  • Chlorpropamide
  • Citalopram
  • Clofibrate
  • Cortisone
  • Diazepam
  • Dicumarol
  • Diltiazem
  • Disopyramide
  • Disulfiram
  • Doxycycline
  • Enalaprilat
  • Enalapril Maleate
  • Enflurane
  • Etoricoxib
  • Fluconazole
  • Fludrocortisone
  • Fosphenytoin
  • Gliclazide
  • Glyburide
  • Haloperidol
  • Isradipine
  • Levomethadyl
  • Levothyroxine
  • Linezolid
  • Losartan
  • Mefloquine
  • Meperidine
  • Metformin
  • Methylprednisolone
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nisoldipine
  • Ospemifene
  • Phenprocoumon
  • Phenytoin
  • Pioglitazone
  • Pirmenol
  • Prednisolone
  • Prednisone
  • Propafenone
  • Raltegravir
  • Repaglinide
  • Rofecoxib
  • Rosiglitazone
  • Sertraline
  • Simvastatin
  • Tadalafil
  • Theophylline
  • Tocainide
  • Triazolam
  • Trimetrexate
  • Valproic Acid
  • Warfarin
  • Zaleplon
  • Zidovudine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • food
  • Tyramine Containing Food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Adrenal gland problem or
  • Blood clotting problems or
  • Diabetes, history of or
  • Porphyria (an enzyme problem) or
  • Vitamin K deficiency—Use with caution. May make these conditions worse.
  • Alcohol abuse, or history of—Use with caution. There may be an increased chance of getting liver problems (eg, hepatitis) if you take this medicine and drink alcohol daily.
  • Gout, acute or
  • Liver disease, acute or severe or
  • Meningococcal disease (including infections of the lining of the brain and spinal cord [meningitis] and bloodstream [eg, bacteremia, septicemia)—Should not be used in patients with these conditions.
  • Liver disease, chronic or
  • Patients with poor nutrition status—Use with caution. May increase risk for vitamin K deficiency, which may lead to excessive bleeding.

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Portions of this document last updated: May 01, 2024

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