Proper Use

Drug information provided by: Micromedex

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.

This medicine should not be given to patients with active tuberculosis (TB). If you know you have TB or think you may have active TB, tell your doctor.

Rifabutin may be taken on an empty stomach (either 1 hour before or 2 hours after a meal). However, if this medicine upsets your stomach, you may want to take it with food.

If you cannot swallow the capsule, you may open it and the contents of the capsules may be mixed with applesauce. Be sure to take all the food to get the full dose of medicine.

To help prevent MAC disease, it is very important that you keep using this medicine for the full time of treatment. You may have to take it every day for many months. It is important that you do not miss any doses.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For the prevention of Mycobacterium avium complex (MAC):
      • Adults—300 milligrams (mg) once a day, or 150 mg two times a day with food.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.