Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on nefazodone have been done only in adult patients, and there is no specific information comparing use of this medicine in children up to 18 years of age with use in other age groups.

Nefazodone must be used with caution in children with depression. Studies have shown occurrences of children thinking about suicide or attempting suicide in clinical trials for this medicine. More study is needed to be sure nefazodone is safe and effective in children.

Geriatric

The relationship of age to the effects of nefazodone has not been systematically studied in older people. However, blood levels of nefazodone have been found to be higher in older patients. An older adult may require a lower dose of nefazodone than a younger adult.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Alprazolam
  • Astemizole
  • Bromopride
  • Carbamazepine
  • Cisapride
  • Colchicine
  • Conivaptan
  • Dihydroergotamine
  • Dronedarone
  • Eletriptan
  • Eliglustat
  • Eplerenone
  • Ergoloid Mesylates
  • Ergonovine
  • Ergotamine
  • Finerenone
  • Flibanserin
  • Furazolidone
  • Gepirone
  • Isavuconazonium Sulfate
  • Isocarboxazid
  • Ivabradine
  • Linezolid
  • Lomitapide
  • Lovastatin
  • Lurasidone
  • Maraviroc
  • Mavacamten
  • Methylergonovine
  • Metoclopramide
  • Naloxegol
  • Nimodipine
  • Pacritinib
  • Phenelzine
  • Pimozide
  • Ranolazine
  • Safinamide
  • Silodosin
  • Simvastatin
  • Terfenadine
  • Tolvaptan
  • Tranylcypromine
  • Triazolam
  • Ubrogepant
  • Venetoclax
  • Voclosporin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab
  • Acalabrutinib
  • Aceclofenac
  • Acemetacin
  • Adagrasib
  • Ado-Trastuzumab Emtansine
  • Alfentanil
  • Almotriptan
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Amphetamine
  • Amtolmetin Guacil
  • Apalutamide
  • Apixaban
  • Aprepitant
  • Aripiprazole
  • Asciminib
  • Aspirin
  • Atogepant
  • Atorvastatin
  • Avacopan
  • Avanafil
  • Avapritinib
  • Axitinib
  • Bedaquiline
  • Benzhydrocodone
  • Benzphetamine
  • Bosutinib
  • Brentuximab Vedotin
  • Brexpiprazole
  • Brigatinib
  • Bromfenac
  • Bromocriptine
  • Budesonide
  • Bufexamac
  • Buprenorphine
  • Bupropion
  • Butorphanol
  • Cabazitaxel
  • Cabozantinib
  • Calcifediol
  • Capivasertib
  • Cariprazine
  • Celecoxib
  • Ceritinib
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clonixin
  • Clopidogrel
  • Clorgyline
  • Clozapine
  • Cobimetinib
  • Codeine
  • Copanlisib
  • Crizotinib
  • Cyclobenzaprine
  • Cyclosporine
  • Dabrafenib
  • Daclatasvir
  • Daridorexant
  • Dasatinib
  • Deflazacort
  • Delamanid
  • Desvenlafaxine
  • Dexamethasone
  • Dexibuprofen
  • Dexketoprofen
  • Dextroamphetamine
  • Dextromethorphan
  • Diclofenac
  • Diflunisal
  • Digoxin
  • Dihydrocodeine
  • Dipyridamole
  • Dipyrone
  • Docetaxel
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Droperidol
  • Droxicam
  • Duloxetine
  • Duvelisib
  • Edoxaban
  • Elacestrant
  • Elagolix
  • Elexacaftor
  • Encorafenib
  • Entrectinib
  • Enzalutamide
  • Eptifibatide
  • Erdafitinib
  • Erlotinib
  • Escitalopram
  • Eszopiclone
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Everolimus
  • Fedratinib
  • Felbinac
  • Fenfluramine
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fesoterodine
  • Fexinidazole
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluticasone
  • Fluvoxamine
  • Fosaprepitant
  • Gilteritinib
  • Glasdegib
  • Granisetron
  • Hydrocodone
  • Hydromorphone
  • Hydroxyamphetamine
  • Hydroxytryptophan
  • Ibrexafungerp
  • Ibrutinib
  • Ibuprofen
  • Idelalisib
  • Ifosfamide
  • Iloperidone
  • Indomethacin
  • Infigratinib
  • Iobenguane I 123
  • Iobenguane I 131
  • Iproniazid
  • Irinotecan
  • Irinotecan Liposome
  • Istradefylline
  • Ivacaftor
  • Ivosidenib
  • Ixabepilone
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lapatinib
  • Larotrectinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Leniolisib
  • Levomilnacipran
  • Levorphanol
  • Lisdexamfetamine
  • Lithium
  • Lorcaserin
  • Lorlatinib
  • Lornoxicam
  • Loxoprofen
  • Lumateperone
  • Lumiracoxib
  • Lurbinectedin
  • Macitentan
  • Manidipine
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Meperidine
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methotrexate
  • Methylene Blue
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Milnacipran
  • Mirtazapine
  • Mirvetuximab Soravtansine-gynx
  • Mitapivat
  • Mobocertinib
  • Moclobemide
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nabumetone
  • Nalbuphine
  • Naproxen
  • Naratriptan
  • Nepafenac
  • Neratinib
  • Nialamide
  • Nifedipine
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nirogacestat
  • Olaparib
  • Oliceridine
  • Omaveloxolone
  • Ondansetron
  • Osilodrostat
  • Oxaprozin
  • Oxycodone
  • Oxymorphone
  • Oxyphenbutazone
  • Ozanimod
  • Palbociclib
  • Palonosetron
  • Palovarotene
  • Panobinostat
  • Parecoxib
  • Pargyline
  • Paroxetine
  • Pazopanib
  • Pemigatinib
  • Pentazocine
  • Pexidartinib
  • Phenylbutazone
  • Piketoprofen
  • Pimavanserin
  • Piperaquine
  • Piroxicam
  • Pirtobrutinib
  • Ponatinib
  • Pralsetinib
  • Pranoprofen
  • Prasugrel
  • Procarbazine
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quetiapine
  • Quizartinib
  • Rasagiline
  • Reboxetine
  • Regorafenib
  • Remifentanil
  • Repotrectinib
  • Retapamulin
  • Ribociclib
  • Rimegepant
  • Rivaroxaban
  • Rizatriptan
  • Rofecoxib
  • Roflumilast
  • Romidepsin
  • Ruxolitinib
  • Salicylic Acid
  • Salmeterol
  • Salsalate
  • Selegiline
  • Selpercatinib
  • Selumetinib
  • Sertraline
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Sirolimus Protein-Bound
  • Sodium Salicylate
  • Sonidegib
  • Sparsentan
  • Sufentanil
  • Sulindac
  • Sumatriptan
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tadalafil
  • Tamsulosin
  • Tapentadol
  • Tazemetostat
  • Temsirolimus
  • Tenoxicam
  • Tezacaftor
  • Thiotepa
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tirofiban
  • Tolfenamic Acid
  • Tolmetin
  • Toloxatone
  • Toremifene
  • Trabectedin
  • Tramadol
  • Upadacitinib
  • Valbenazine
  • Valdecoxib
  • Vamorolone
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vilazodone
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Vorapaxar
  • Vortioxetine
  • Zanubrutinib
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amlodipine
  • Aripiprazole Lauroxil
  • Buspirone
  • Foxglove
  • Ginkgo
  • Haloperidol
  • Methylprednisolone
  • Pravastatin
  • Ritonavir
  • St John's Wort

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Convulsions (seizures) (history of)—The risk of seizures may be increased
  • Dehydration or
  • Hypovolemia (low blood volume)—May increase the chance that low blood pressure (hypotension) will occur
  • Heart disease or
  • Stroke (or history of)—Nefazodone may make these conditions worse by causing low blood pressure (hypotension)
  • Liver function problems—If your liver does not function well, due to liver problems or liver disease and you take nefazodone, the amount of nefazodone in your blood may be too high. This may cause serious disease or damage in your liver.
  • Liver function problems when taking this medicine before and you had to stop taking it—You may have a greater chance of having liver problems if you take nefazodone again. Tell your doctor immediately if you have taken this medicine before.
  • Mania (a type of mental illness) (history of)—Nefazodone may cause this problem to recur

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.