Before Using

Drug information provided by: Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of nateglinide in children with use in other age groups.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, older patients may be more likely to develop low blood sugar.

Pregnancy

Information about this nateglinide-oral-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine
  • Ceritinib
  • Crizotinib
  • Dabrafenib
  • Entacapone
  • Eslicarbazepine Acetate
  • Idelalisib
  • Metreleptin
  • Mitotane
  • Nitisinone
  • Piperaquine
  • Primidone
  • Siltuximab

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Bitter Melon
  • Eltrombopag
  • Glucomannan
  • Guar Gum
  • Psyllium

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Adrenal gland or pituitary gland not producing enough hormones or
  • Malnourishment (not getting enough nutrients in your diet) or
  • Severe kidney problems—These conditions can make patients on nateglinide be more at risk for having low blood sugar.
  • Alcohol use or
  • Not eating enough or
  • Strenuous physical exercise—May increase risk of low blood sugar
  • Fever or
  • Infection or
  • Surgery or
  • Trauma—Temporary loss of blood sugar control may occur in patients with these conditions. Insulin therapy may be needed.
  • Ketones in the blood (diabetic ketoacidosis) or
  • Type 1 (insulin-dependent) diabetes—Insulin is needed to control diabetes in patients with these conditions
  • Liver disease, moderate to severe—Use of nateglinide in patients with this condition have not been studied. Caution should be used.
  • Nervous system disorder (autonomic neuropathy)—Patients with this condition might not be able to detect the symptoms of low blood sugar and might not take immediate steps to treat it