Proper Use

Drug information provided by: Merative, Micromedex®

This medicine is given as a shot under your skin, usually in the abdomen or stomach, thighs, or upper arms.

Mipomersen may sometimes be given at home to patients who do not need to be in the hospital. If you are using this medicine at home, your doctor will teach you how to prepare and inject the medicine. Be sure that you understand exactly how the medicine is prepared and injected.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections.

This medicine is usually given once a week, on the same day every week. Do not inject on skin areas that have cuts, scrapes, infection, scars, sunburns, or tattoos.

The prefilled syringe should be removed from the refrigerator and allowed to reach room temperature for at least 30 minutes prior to injection. Do not remove the needle cover of the prefilled syringe while allowing the syringe to reach room temperature.

Use each syringe only one time. Do not save an open syringe. If the medicine in the syringe has changed color, or if you see particles in it, do not use it.

In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Carefully follow your doctor's order about any special diet.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For high cholesterol:
      • Adults—200 milligrams (mg) injected under your skin once a week.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

If you missed a dose of this medicine, use this medicine at least 3 days before the next weekly dose.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may also store the medicine at or below 30 degrees C (86 degrees F), away from heat sources, for up to 14 days. Protect the medicine from light. Keep your medicine in the original package until you are ready to use it.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Portions of this document last updated: Feb. 01, 2024

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