Interactions

Interactions with Drugs

Milk thistle may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be increased in the blood, and may cause increased effects or potentially serious adverse reactions. People using any medications should check the package insert, and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.

Milk thistle may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.

Milk thistle may also interact with agents that affect the blood, agents that promote milk production, agents that affect the liver, agents used for the skin, heart, stomach, or intestines, alcohol, amiodarone, anti-anxiety agents, anti-inflammatories, anticancer agents, antiretrovirals, antivirals, cholesterol-lowering agents, fertility agents, glucuronidated agents, hormonal agents, impotence agents, irinotecan, losartan, penicillin, phenytoin (Dilantin®), p-glycoprotein modulators, rapamycin, and talinolol.

Interactions with Herbs and Dietary Supplements

Milk thistle may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may be too high in the blood, and may cause increased effects or potentially serious adverse reactions.

Milk thistle may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

Milk thistle may also interact with anti-anxiety herbs and supplements, anti-inflammatories, anticancer herbs and supplements, antioxidants, antiretrovirals, antivirals, calcium, cholesterol-lowering herbs and supplements, fertility herbs and supplements, glucuronidated herbs and supplements, herbs and supplements that affect the blood, herbs and supplements that promote milk production, herbs and supplements that affect the liver, herbs and supplements used for the skin, heart, stomach, or intestines, hormonal herbs and supplements, impotence herbs and supplements, iron, N-acetyl cysteine, p-glycoprotein modulators, and vitamin E.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com