Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (over 18 years old)

For acute viral hepatitis, 160-800 milligrams of silymarin (e.g. Legalon®) has been taken by mouth daily in three divided doses for three weeks.

For allergic nasal symptoms, 140 milligrams of silymarin has been taken by mouth three times daily for one month.

For amanita phalloides mushroom toxicity, silibinin has been taken by mouth; 20-50 milligrams per kilogram of silibinin in 500 milliliters of 5% dextrose solution has been injected into the vein every six hours for one day.

For antioxidant effects, 140 milligrams of silymarin (Livergol®) has been taken by mouth three times daily for three weeks.

For cirrhosis, 160-800 milligrams of silymarin (e.g. Legalon®) has been taken by mouth in 2-3 divided doses daily by mouth for up to two years.

For diabetes (type 2), 200-230 milligrams of silymarin (e.g. Legalon®) has been taken by mouth one to three times daily for four weeks to 12 months, together with regular therapy.

For diabetic nephropathy (kidney disease), 140 milligrams of silymarin has been taken by mouth three times daily for three months.

For liver damage from drugs or toxins, 160-800 milligrams of silymarin (e.g. Legalon®) has been taken by mouth daily in three divided doses for periods ranging from 15 days to five weeks; 70 milligrams of silibinin has been taken by mouth three times daily for 6-12 months.

For fertility, three doses of 70 milligrams of silymarin have been taken by mouth (in addition to standard therapy) over the course of one day.

For high cholesterol, 200-600 milligrams of silymarin has been taken by mouth once or three times daily for four months in addition to standard therapy.

For chronic liver disease 160-480 milligrams of silybin (Silipide®, IdB 1016) has been taken by mouth once or three times daily for up to three months;120-420 milligrams of silymarin (Legalon®) has been taken by mouth daily in three divided doses for four weeks to 12 months; silibinin (e.g. Legalon® SIL) has been injected into the vein for periods of 10-14 days.

For osteoarthritis, 150 milligrams of silymarin has been taken by mouth twice daily for eight weeks.

For radiation skin irritation, a silymarin-based cream (Leviaderm®) has been applied to the skin.

Children (under 18 years old)

For liver damage from drugs or toxins, 80-320 milligrams of silibinin has been taken by mouth daily for 28 days.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com