Before Using

Drug information provided by: Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of metoclopramide in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of metoclopramide in the elderly. However, elderly patients are more likely to have side effects such as tardive dyskinesia, confusion, or drowsiness, and age-related kidney problems, which may require an adjustment in the dose for patients receiving metoclopramide.

Pregnancy

Information about this metoclopramide-oral-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amitriptyline
  • Amoxapine
  • Aripiprazole
  • Asenapine
  • Bupropion
  • Chlorpromazine
  • Citalopram
  • Clomipramine
  • Clozapine
  • Desipramine
  • Desvenlafaxine
  • Doxepin
  • Duloxetine
  • Escitalopram
  • Fluoxetine
  • Fluphenazine
  • Fluvoxamine
  • Haloperidol
  • Iloperidone
  • Imipramine
  • Loxapine
  • Lurasidone
  • Maprotiline
  • Mesoridazine
  • Mirtazapine
  • Molindone
  • Nefazodone
  • Nortriptyline
  • Olanzapine
  • Paliperidone
  • Paroxetine
  • Perphenazine
  • Pimozide
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Protriptyline
  • Quetiapine
  • Risperidone
  • Rivastigmine
  • Thioridazine
  • Thiothixene
  • Trazodone
  • Trifluoperazine
  • Trimethobenzamide
  • Venlafaxine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Bromocriptine
  • Isocarboxazid
  • Linezolid
  • Milnacipran
  • Phenelzine
  • Rasagiline
  • Selegiline
  • Tramadol
  • Tranylcypromine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclosporine
  • Didanosine
  • Digoxin
  • Levodopa
  • Mivacurium
  • Posaconazole
  • Sertraline
  • Succinylcholine
  • Tacrolimus
  • Thiopental

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Abdominal or stomach bleeding or
  • Intestinal blockage or perforation (hole in the intestine) or
  • Pheochromocytoma (adrenal gland tumor) or
  • Seizures or epilepsy—Should not be used in patients with these conditions.
  • Asthma or
  • Cirrhosis (liver disease) or
  • Congestive heart failure or
  • Diabetes or
  • Heart rhythm problems (e.g., ventricular arrhythmia) or
  • Hypertension (high blood pressure) or
  • Mental depression, or history of or
  • Neuroleptic malignant syndrome, history of or
  • Parkinson's disease, history of—Use with caution. May make these conditions worse.
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency (an enzyme problem) or
  • Nicotinamide adenine dinucleotide (NADH) cytochrome reductase deficiency (an enzyme problem)—May increase the risk for side effects affecting the blood.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.