Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (18 years and older)

Many available studies have looked at the effects of mixed-ingredient therapies that contain lycopene. These include Lyc-O-Mato® and LycoRed® (both manufactured by LycoRed Natural Products Industries Ltd., Beer-Sheva, Israel). According to the manufacturer, these two supplements contain lycopene and other nutrients found in whole tomatoes. The effects of lycopene alone are unable to be determined from these studies. However, due to the wealth of information on the use of these mixed-ingredient products, doses that have been used are outlined below.

As an antioxidant, lycopene has been taken by mouth in doses of 6.5, 15, and 30 milligrams daily for eight weeks. Lyc-O-Mato® capsules (each containing up to 15 milligrams) have been taken by mouth once daily for eight weeks and 26 days, or twice daily for four months. Two capsules of LycoRed® (each containing 15 milligrams of lycopene) have been taken by mouth once daily for 21 days.

To treat asthma caused by exercise, 30 milligrams of lycopene in the form of Lyc-O-Mato® has been taken by mouth daily for one week.

To treat coronary artery disease, 1.24 grams of six-percent lycopene oleoresin capsules (LycoRed®) has been taken by mouth daily for one week. Two LycoRed® softules (each containing 2,000 micrograms of lycopene) have been taken by mouth daily for six months. Lycopene has been taken by mouth in the form of tomato products, capsules, and Lyc-O-Mato® in doses of 39.2-80 milligrams for 1-12 weeks.

To treat enlarged prostate, 15 milligrams of lycopene (LycoVit®) has been taken by mouth daily for six months.

To treat brain tumors, eight milligrams of lycopene has been taken by mouth daily for three months.

To treat heart disease, lycopene has been taken by mouth in the form of tomato products, capsules, and Lyc-O-Mato® in doses of 39.2-80 milligram doses daily for 1-12 weeks.

To treat gum disease, LycoRed® (providing eight milligrams of lycopene) has been taken by mouth daily in divided doses for two weeks.

To treat high blood pressure, lycopene has been taken by mouth in 4-44-milligram doses daily for up to six months. Lyc-O-Mato®, containing 15 milligrams of lycopene, has been taken by mouth daily for six weeks and eight weeks. A dose of 250 milligrams of Lyc-O-Mato® has been taken by mouth for eight weeks.

To treat infertility, 2,000 micrograms of lycopene has been taken by mouth twice daily for three months.

To lower lipid levels, lycopene has been taken by mouth in 4-44-milligram doses daily for up to six months. Two LycoRed® softules (each containing 2,000 micrograms of lycopene) have been taken by mouth daily for six months.

To treat mouth sores, LycoRed®, containing 4-8 milligrams of lycopene, has been taken by mouth daily for three months in two divided doses.

To treat inflammation of the mouth, 16 milligrams of lycopene has been taken by mouth daily in two divided doses for two months.

To prevent ovarian cancer, 4,000 micrograms of lycopene has been taken by mouth daily.

To treat high blood pressure associated with pregnancy, LycoRed® (containing two milligrams of lycopene per capsule) has been taken once or twice daily until delivery.

To prevent or treat prostate cancer, two milligrams of lycopene has been taken by mouth twice daily, and four milligrams of lycopene has been taken by mouth twice daily for one year. Lyc-O-Mato®, containing up to 120 milligrams of lycopene, has also been taken by mouth in divided doses twice daily for periods of up to one year. LycoRed® softules, providing a total daily dose of 10 milligrams of lycopene, have been taken daily for three months.

To protect skin from sun damage, 55 grams of tomato paste in olive oil (providing 16 milligrams of lycopene) has been taken by mouth daily for 12 weeks.

Children (younger than 18 years)

There is no proven safe or effective dose for lycopene in children.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com