Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take this medicine at the same time each day.

Swallow the capsule or tablet whole with a glass of water. Do not open, crush, break, or chew it.

Measure the oral liquid medicine with the provided oral dosing syringe.

Drink plenty of water each day to help prevent dehydration caused by diarrhea.

Do not drink grapefruit juice or eat grapefruit or Seville oranges with this medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules, tablets, or suspension):
    • For chronic graft versus host disease:
      • Adults and children 12 years of age and older—420 milligrams (mg) once a day. Your doctor may adjust your dose as needed and tolerated.
      • Children 1 to younger than 12 years of age—Dose is based on body surface area (BSA) and must be determined by your doctor. The dose is usually 240 milligrams per square meter (mg/m[2]) once a day. Your doctor may adjust your dose as needed and tolerated.
      • Children younger than 1 year of age—Use and dose must be determined by your doctor.
    • For chronic lymphocytic leukemia or small lymphocytic lymphoma alone or together with bendamustine and rituximab or obinutuzumab, or Waldenström macroglobulinemia alone or together with rituximab:
      • Adults—420 milligrams (mg) once a day. Your doctor may adjust your dose as needed and tolerated.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Take the missed dose only if it is the same day as the scheduled dose.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away any unused oral liquid 60 days after opening the bottle.

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