The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (18 years and older)
Note: Full benefit of glucosamine may take up to one month in some people. Glucosamine hydrochloride may provide more glucosamine than the glucosamine sulfate salt form.
To treat bone diseases (Kashin-Beck disease), 480 milligrams of glucosamine hydrochloride has been taken by mouth three times daily for six months, as well as 750 milligrams of glucosamine hydrochloride by mouth twice daily for six weeks.
To treat circulation problems (chronic venous insufficiency), Perclar® has been taken by mouth at doses of 48 milligrams, 72 milligrams, or 96 milligrams.
To treat high cholesterol, 1,500 milligrams of glucosamine, 1,527 milligrams of glucosamine sulfate (equivalent to 1,200 milligrams glucosamine), or 750 milligrams glucosamine hydrochloride (equal to 625 milligrams glucosamine) has been taken by mouth daily for up to 14 weeks.
To treat knee osteoarthritis, 300-500 milligrams of glucosamine sulfate or 480 milligrams of glucosamine hydrochloride has been taken by mouth three times daily for up to 12 weeks.
To treat low back pain, 1500 milligrams of glucosamine has been taken by mouth daily for six months. Additionally, 3 milliliters of glucosamine sulfate cream or 3 milliliters of glucosamine sulfate have been given through the skin via iontophoresis (using electricity to deliver the drug) or massaged into the skin for 15 minutes, three times weekly for four weeks.
To treat multiple sclerosis, 1000 milligrams daily of glucosamine sulfate has been taken by mouth for six months.
To treat osteoarthritis (general), 1000-2000 milligrams daily of glucosamine, glucosamine sulfate, or glucosamine hydrochloride in the form of tablets, capsules, or crystalline powder has been taken by mouth for up to 18 months. Up to 400 milligrams of glucosamine has also been injected into the joint, vein, or muscle for varying durations.
To treat rheumatoid arthritis, 420 milligrams of Teoremac® has been taken by mouth daily for 14 days.
Children (under 18 years old)
Glucosamine is not suggested in children, due to lack of data. Research suggests that there may be a link between autism and methylsulfonylmethane (MSM), which is often marketed with glucosamine. However, there is still a lack of information. Doses of 3-6 grams of N-acetyl-glucosamine have been used to treat inflammatory bowel disease in children.
This evidence-based monograph was prepared by The Natural Standard Research Collaboration