Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Magnevist

Descriptions


Gadopentetate is a magnetic resonance imaging (MRI) contrast agent. Contrast agents are used to help create a clear picture of the body during MRI scans. MRI scans are a special kind of diagnostic procedure. They use magnets and computers to create images or “pictures” of certain areas inside the body. Unlike x-rays, they do not involve ionizing radiation. Gadopentetate is a gadolinium-based contrast agent (GBCA).

Gadopentetate is given by injection before MRI to help diagnose problems in the brain, spine, head, neck, and other parts of your body.

This medicine is to be used only by or under the direct supervision of a doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of gadopentetate in children 2 years of age and older. However, safety and efficacy have not been established in children younger than 2 years of age.

Geriatric

No information is available on the relationship of age to the effects of gadopentetate in geriatric patients.

Pregnancy

Information about this gadopentetate-intravenous-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma or allergies, history of or
  • Patients who have had prior reactions to contrast media—Use with caution. May increase the likelihood of an allergic reaction.
  • Diabetes or
  • Hypertension (high blood pressure)—Use with caution. May increase your likelihood of having reduced kidney function.
  • Kidney disease, mild or moderate—Use with caution. May increase the likelihood of serious side effects.
  • Kidney problems, severe (acute or long-term)—Should not be used in patients with this condition.

Proper Use

A doctor or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins just before you have an MRI scan.

Precautions

It is very important that your doctor check the progress of you or your child while you are receiving this medicine and during the MRI scan. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects.

The risk of having a very serious disease called nephrogenic systemic fibrosis (NSF) is increased in patients with severe kidney disease. Even if you have severe kidney problems, your doctor may decide that it is still important to use this medicine. Check with your doctor right away if you or your child have burning or itching of the skin, red or dark patches on the skin, swelling, hardening, or tightening of the skin, joint stiffness, limited range of motion in the arms and legs, pain that is deep in the hip bone or ribs, or muscle weakness. These may be symptoms of NSF.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Check with your doctor or nurse right away if you or your child have cold, clammy skin, confusion, dizziness, lightheadedness, a skin rash, itching, sweating, swelling of the face, tongue, and throat, trouble with breathing, or chest pain after you receive the medicine.

Tell your doctor right away if you or your child have mild, burning pain, feeling of warmth or coldness, peeling of the skin, redness, or swelling at the injection site.

Make sure your doctor knows that you or your child have used this medicine. This medicine may affect the results of certain medical tests (e.g., serum iron, bilirubin, or transaminase levels).

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

  1. Arm, back, or jaw pain
  2. bluish color
  3. blurred vision
  4. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  5. changes in skin color
  6. chest pain or discomfort
  7. chest tightness or heaviness
  8. chills
  9. confusion
  10. cough
  11. difficult or labored breathing
  12. difficulty with swallowing
  13. dizziness
  14. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  15. fainting
  16. fast, pounding, or irregular heartbeat or pulse
  17. fever
  18. headache
  19. headache, severe and throbbing
  20. hives
  21. irritation of the throat
  22. itching
  23. loss of bladder control
  24. loss of consciousness
  25. nausea
  26. nervousness
  27. noisy breathing
  28. pain or swelling of the treated skin
  29. paleness of the skin
  30. pounding in the ears
  31. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  32. red or irritated eyes
  33. redness, tenderness, itching, burning, or peeling of the skin
  34. runny nose
  35. seizures
  36. shortness of breath
  37. skin rash
  38. slow or fast heartbeat
  39. sneezing
  40. sore throat
  41. stuffy nose
  42. sweating
  43. swelling of the foot or leg
  44. swelling or puffiness of the face
  45. tenderness
  46. total body jerking
  47. unusual tiredness or weakness
  48. wheezing

Incidence not known

  1. Agitation
  2. blistering, peeling, or loosening of the skin
  3. bluish color of the fingernails, lips, skin, palms, or nail beds
  4. burning or itching of the skin
  5. change in consciousness
  6. coma
  7. coughing that sometimes produces a pink frothy sputum
  8. decreased urine output
  9. depression
  10. diarrhea
  11. difficult, fast, or noisy breathing, sometimes with wheezing
  12. difficulty with speaking
  13. frequent strong or increased urge to urinate
  14. hoarseness
  15. hostility
  16. increased sweating
  17. irritability
  18. joint or muscle pain
  19. joint stiffness
  20. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  21. lethargy
  22. limited range of motion in the arms and legs
  23. muscle twitching or weakness
  24. no blood pressure or pulse
  25. no breathing
  26. pain that is deep in the hip bone or ribs
  27. pain, redness, or swelling in the arm or leg
  28. rapid weight gain
  29. red or dark patches on the skin
  30. shakiness in the legs, arms, hands, or feet
  31. skin swelling, hardening, or tightening
  32. slow or irregular breathing
  33. sores, ulcers, or white spots in the mouth or on the lips
  34. spots on your skin resembling a blister or pimple
  35. stopping of heart
  36. stupor
  37. swelling of the face, ankles, or hands
  38. tenderness
  39. tightness in the chest
  40. trembling or shaking of the hands or feet
  41. troubled breathing
  42. unconsciousness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Rare

  1. Abdominal or stomach discomfort or pain
  2. bad, unusual, or unpleasant (after) taste
  3. burning, dry, or itching eyes
  4. change in taste
  5. continuing ringing or buzzing or other unexplained noise in the ears
  6. decrease or change in vision
  7. difficulty having a bowel movement (stool)
  8. discharge or excessive tearing
  9. double vision
  10. dry mouth
  11. ear pain
  12. eye pain
  13. feeling cold or warm
  14. hearing loss
  15. hives or welts
  16. hyperventilation
  17. increased salivation
  18. lack or loss of strength
  19. loss of appetite
  20. nervousness
  21. pain in the tooth
  22. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  23. restlessness
  24. seeing double
  25. skin rash
  26. sleepiness or unusual drowsiness
  27. tearing of the eyes
  28. thirst
  29. trouble sleeping
  30. uncontrolled eye movements
  31. vomiting
  32. weight loss

Incidence not known

  1. Blurred or loss of vision
  2. change in sense of smell
  3. difficulty with moving
  4. disturbed color perception
  5. double vision
  6. halos around lights
  7. muscle pain or stiffness
  8. night blindness
  9. overbright appearance of lights
  10. poor hearing
  11. tunnel vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.