Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (over 18 years old)

General:The daily suggested intake levels of folic acid are as follows: males over 13 years, 400 micrograms; females over 13 years, 400-600 micrograms; pregnancy all ages, 400-600 micrograms; breastfeeding females of all ages, 500 micrograms. The maximum daily intake level of folic acid for people 19 years and older (including pregnant or breastfeeding women), 1,000 micrograms.

For anemia caused by folate deficiency, 1-5 milligrams has been taken by mouth daily until recovery.

For antiseizure drug-induced folate deficiency, 15 milligrams has been taken by mouth daily under the supervision of a qualified healthcare provider.

For bipolar disorder, 200 international units of folic acid has been taken by mouth daily for 52 weeks in patients stabilized on lithium. Three milligrams of folic acid have been taken by mouth daily for three weeks in patients starting valproic acid therapy.

For cancer (general), 0.2-40 milligrams of folate or folic acid (either taken alone or in combination with aspirin, vitamin B6, or vitamin B12) has been taken by mouth daily for 3-8 years, with mixed results.

For cognitive effects, 0.75-15 milligrams of folic acid has been taken by mouth daily for 1-36 months.

For colorectal cancer, 0.5-5 milligrams of folic acid has been taken by mouth daily for 3-8 years with mixed results.

For chronic kidney disease, 2-15 milligrams of folic acid has been taken by mouth daily, every other day or three times weekly, for a follow-up duration of 1-3.6 years.

For depression, 0.5-3 milligrams or 200 international units of folic acid or 15-50 milligrams of methylenetetrahydrofolate have been taken by mouth daily for 3-52 weeks.

For diabetes, 5 milligrams of folic acid has been taken by mouth daily for 1-6 months.

For folate deficiency, 250-1,000 micrograms has been taken by mouth daily. In addition, for severe folate deficiency, 1-5 milligrams has been taken by mouth daily until blood levels are corrected and documented by a qualified healthcare professional.

For fragile X syndrome, 10-250 milligrams of folic acid has been taken by mouth daily for 2-8 months with a lack of effect on symptoms.

For heart disease, 0.8-40 milligrams of folic acid have been taken by mouth daily for 3-88 months.

For high homocysteine levels, 0.2-5 milligrams of folic acid has been taken by mouth for 21-168 days.

For high blood pressure, 5-10 milligrams of folic acid has been taken by mouth for 2-16 weeks.

For methotrexate toxicity, 1-27.5 milligrams of folic acid or 1-20 milligrams of folinic acid has been taken by mouth daily or weekly for up to 12 weeks.

For the prevention of birth defects, wheat flour fortified with folic acid has been taken by mouth before pregnancy and during the first two months of pregnancy. Doses of 0.36-5 milligrams have been taken by mouth daily.

For the prevention of pregnancy complications (other), 0.25-5 milligrams of folic acid have been taken by mouth daily for 12-24 weeks.

For stroke, 0.5-40 milligrams of folic acid have been taken by mouth daily for 6-88 months.

For vein clots, 5 milligrams of folic acid has been taken by mouth once daily during pregnancy.

For vitiligo, 5 milligrams has been taken by mouth twice daily.

For gum overgrowth caused by phenytoin, folic acid has been applied to the gum.

For pregnancy-related gum disease, folic acid has been applied to the gum.

Children (under 18 years old)

The daily suggested intake levels of folic acid are as follows: babies 0-6 months, 65 micrograms; 7 to 12 months, 80 micrograms; children 1-3 years, 150 micrograms; 4-8 years, 200 micrograms; males 9-13 years, 300 micrograms; males over 13 years, 400 micrograms; and females 9-13 years, 300 micrograms.

The maximum daily intakes are as follows: for children 1-3 years-old, 300 micrograms; for children 4-8 years-old, 400 micrograms; for children 9-13 years-old, 600 micrograms; and for adolescents 14-18 years-old, 800 micrograms. Folic acid injection contains benzyl alcohol (1.5 percent), and extreme care should be used when given to newborns. Folic acid injections should be given by a healthcare provider.

For fragile X syndrome, 10-250 milligrams has been taken by mouth daily for 2-8 months with a lack of effect on symptoms.

For general health maintenance, 0.005-15 milligrams has been taken by mouth daily for two weeks to 18 months, with mixed results.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com