Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (18 years and older)

To treat symptoms of adrenal insufficiency (hormone production problems), 20-200 milligrams of DHEA has been taken by mouth daily for up to 12 months.

To treat AIDS/HIV, 50-2,250 milligrams of DHEA has been taken by mouth for up to sixteen weeks.

To improve bone density, doses of 50-200 milligrams of DHEA have been taken by mouth daily for up to two years.

To treat cervical cancer, 150 milligrams of DHEA has been applied to the vagina daily for up to six months.

To treat chronic fatigue syndrome, up to 500 milligrams of DHEA has been taken by mouth daily for up to six months.

To treat chronic obstructive pulmonary disease (COPD), 200 milligrams of DHEA has been taken by mouth daily for three months.

To treat cognitive disorders, 25-400 milligrams of DHEA has been taken by mouth daily for up to six months. A dose of 200 milligrams of DHEA-S has been injected into the vein daily for four weeks.

To treat depression, 5-450 milligrams of DHEA has been taken by mouth daily for up to six weeks, alone or in addition to antidepressants. DHEA has been taken by mouth starting at a dose of 100 milligrams up to 500 milligrams daily for eight weeks (increasing by 100 milligrams each week).

To treat diabetes, 25-75 milligrams of DHEA has been taken by mouth daily for up to one year. Higher doses of 1,600 milligrams of DHEA have also been taken by mouth daily for 28 days. An infusion of 1 milligram of DHEA has been injected into the blood hourly for a total of 17 hours.

To treat drug withdrawal, 100 milligrams of DHEA has been taken daily by mouth for 12 weeks and 12 months.

To treat fibromyalgia, 50 milligrams of DHEA has been taken by mouth daily for three months.

To treat heart disease, 25-150 milligrams of DHEA has been taken by mouth daily for up to two years.

As an immune system stimulant, 50 milligrams of DHEA has been taken by mouth daily for 20 weeks.

To treat infertility, 25-80 milligrams of DHEA has been taken by mouth daily for at least six weeks and up to four months.

To treat inflammatory bowel disease, 200 milligrams of DHEA has been taken by mouth daily for 56 days.

To induce labor, 10 milligrams of DHEA-S dissolved in 10 milliliters of 5% glucose solution has been injected into the blood twice weekly after 38 weeks gestation. A dosage of 100 milligrams of DHEA-S in 250 milliliters of 5% levulose solution has been injected into the blood daily for three days. Additionally, 200 milligrams of DHEA-S has been injected into the blood once or twice weekly beginning at 37 weeks gestation. Multiple doses of 50 milligrams or 100 milligrams of DHEA-S have been injected during weeks 38-42 of pregnancy.

To treat lupus, 20-200 milligrams of DHEA has been taken daily for up to two years.

To treat menopause, 10-50 milligrams of DHEA has been taken by mouth daily for up to 12 months. Additionally, 100 milligrams of DHEA-S has been taken by mouth daily for three months.

To prevent miscarriage, 25 milligrams of DHEA has been taken by mouth three times daily for at least two months.

To improve muscle strength, 50-150 milligrams of DHEA has been taken by mouth daily for up to 12 months.

To treat myotonic dystrophy (muscle wasting and weakness), 100 milligrams and 400 milligrams of DHEA have been taken by mouth daily for 12 weeks. Additionally, 200 milligrams of DHEA-S has been injected into a vein for eight weeks.

To treat obesity, 50-200 milligrams of DHEA, 7-oxo-DHEA or 7-Keto has been taken by mouth daily for up to 12 months. Additionally, 400 milligrams of DHEA has been taken by mouth four times daily for 28 days. A dosage of 40 milligrams of DHEA placed under the tongue has been taken twice daily for eight weeks.

To treat partial androgen deficiency, 25 milligrams of DHEA has been taken by mouth daily for one year.

To treat psoriasis, 300 milligrams of DHEA-enanthate has been injected into the muscle daily.

To treat rheumatoid arthritis, 200 milligrams of DHEA has been taken by mouth daily for 16 weeks.

To treat schizophrenia, DHEA has been taken by mouth at a starting dose of 25 milligrams by mouth daily for two weeks, then 50 milligrams daily in divided doses for two weeks, and then 100 milligrams daily in divided doses for a final two weeks. Additionally, 200 or 400 milligrams of DHEA has been taken by mouth daily for up to eight weeks.

To treat sexual dysfunction/libido/erectile dysfunction, 20-75 milligrams of DHEA has been taken by mouth for up to six months. A single dose of 300 milligrams of DHEA has been taken by mouth. Additionally, 90 milligrams of DHEA has been taken by mouth daily for three weeks followed by 450 milligrams daily for three weeks. A dose escalation of DHEA from 100 milligrams to 400 milligrams daily for eight weeks (increasing by 100 milligrams at weekly intervals) has been taken by mouth.

To treat Sjögren's syndrome, 50-200 milligrams of DHEA has been taken by mouth daily for up to one year.

To treat skin aging, 0.1-2% DHEA has been applied once or twice daily to the face, hands, upper chest, and thighs for up to four months.

To treat vaginal atrophy, daily doses of 0.25%, 0.5%, and 1.0% DHEA (prasterone; Vaginorm™) have been applied to the vagina for 12 weeks.

Children (younger than 18 years)

There is no proven safe or effective dose for DHEA in children. DHEA may interfere with hormonal development.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com