Interactions with Drugs
Creatine may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
Creatine may also interact with agents eliminated by the kidneys; agents for cancer, diabetes, epilepsy, gout, or osteoporosis; agents for the brain or heart; agents that alter immune function; agents that increase urination; agents toxic to the liver or kidneys; aminoglycosides; anti-aging agents; anti-inflammatory agents; antiviral agents; athletic performance-enhancing agents; caffeine; calcium-channel blockers; cholesterol lowering agents; cimetidine; CNS stimulants; digoxin; ergot derivatives; gallium nitrate; glutamate inhibitors; insulin; nifedipine; probenecid; sodium bicarbonate; tacrolimus; and valacyclovir.
Interactions with Herbs and Dietary Supplements
Creatine may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
Creatine may also interact with alpha-lipoic acid; anti-aging herbs and supplements; anti-inflammatory herbs and supplements; antiviral herbs and supplements; arginine; athletic performance-enhancing herbs and supplements; caffeine; cholesterol lowering herbs and supplements; ephedra; herbs and supplements eliminated by the kidneys; herbs and supplements for cancer, diabetes, epilepsy, gout, or osteoporosis; herbs and supplements for the brain or heart; herbs and supplements that increase urination; herbs and supplements toxic to the liver or kidneys; hydroxymethylbutyrate; L-arginine; L-glycine; magnesium; phosphatidylcholine; pyruvate; and vitamins A, D, E, and K.
This evidence-based monograph was prepared by The Natural Standard Research Collaboration