Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (18 years and older)

For aging, 0.3 grams/kilogram of creatine has been taken by mouth for five days, followed by 0.07grams/kilogram by mouth for 79 days.

For amyotrophic lateral sclerosis (ALS), 3-30 grams of creatine has been taken by mouth daily for seven days to 56 weeks, in one or two divided doses.

For bone density, 0.3 grams/kilogram of creatine has been taken daily by mouth for five days, followed by 0.07 grams/kilogram daily by mouth for 79 days.

For chronic obstructive pulmonary disorder (COPD), 17.1-22 grams of creatine has been taken daily by mouth for five days to two weeks, followed by 3.76-5.7 grams daily for seven to 12 weeks. A dosage of 0.3 grams/kilogram of creatine has been taken daily by mouth for seven days, followed by 0.07 grams/kilogram daily for seven weeks.

For cognitive function, 0.03 grams/kilogram of creatine has been taken daily by mouth for six weeks. In people with blocked coronary arteries, 2 grams of creatine phosphate has been injected into the blood over a two-hour time period, followed by 8 grams of creatine phosphate injected into the blood on the day of admission. Individuals also received 2 grams of creatine phosphate injected into the blood twice daily at the rate of 4 milliliters/minute for two additional days after admission. The total dose of creatine phosphate was 18 grams over three days.

For congestive heart failure, 20 grams of creatine has been taken by mouth daily for five days. Doses of 5-6 grams have been injected into the blood for up to five days. Additionally, 2 grams has been injected into the blood daily for two weeks, followed by 0.5 grams injected into the muscle daily for one month. One gram injected into the blood daily for seven days has also been used.

For coronary heart disease (surgery), 4 grams of creatine has been injected into the blood daily for three days with cardioplegic solution. Additionally, 10 millimoles/liter of creatine with cardioplegic solution has been given.

For dehydration, 0.3 grams/kilogram of creatine has been taken by mouth daily or 10-25 grams has been taken in 1-2 divided doses daily for 5-28 days.

For depression, 3-5 grams of creatine has been taken by mouth daily for four weeks.

For diabetes (type 2), 3 grams of creatine has been taken by mouth once or twice daily for five days.

For dialysis, 2 grams of creatine has been taken by mouth daily for two treatment periods of four weeks, separated by a washout of four weeks. A dose of 12 milligrams of creatine has been taken by mouth before each dialysis session for four weeks. Additionally, 12 milligrams of creatine before each dialysis session has been injected into the blood for four weeks.

For enhanced athletic performance (loading dose), the typical dosing is four times daily for loading and twice daily for maintenance. Water intake should be 64 ounces daily to avoid dehydration. To rapidly increase muscle creatine levels and increase muscle mass or strength, 9-25 grams or 0.25-0.3 gram/kilogram of creatine has been taken by mouth daily for 4-7 days.

For enhanced athletic performance (maintenance dose), 2-20 grams of creatine has been taken by mouth daily for five days to 12 weeks. A dose of 0.03-0.15 gram/kilogram of creatine has been taken by mouth daily for up to seven weeks, twice or thrice weekly, as has 10 grams of creatine daily for three weeks following a loading dose.

For enhanced athletic performance (aging), 5-20 grams or 0.25-0.5 gram/kilogram of creatine has been taken by mouth daily for five days to 14 weeks or three days weekly for 12 weeks. 0.3 gram/kilogram or 20 grams of creatine has been taken by mouth daily for 5-10 days, followed by 0.07 gram/kilogram or 4 grams by mouth daily for approximately 20 days to 11 weeks.

For enhanced athletic performance (cyclists), 25 grams of creatine by mouth daily for five days plus 5 grams per hour during testing has been used. A dosage of 5-20 grams of creatine by mouth daily for 5-7 days has been used

For enhanced athletic performance (endurance; general), 6-25 grams of a creatine loading dose has been taken daily for 5-7 days or for five days before exercise. 20 grams of creatine has been taken daily for seven days, followed by 2 grams daily for maintenance.

For enhanced athletic performance (high-intensity endurance), 0.25-0.3 grams/kilogram, 2.25 grams, 10 grams, 20 grams, or 25 grams of creatine has been taken by mouth daily for 5 days to six weeks.

For enhanced athletic performance (rowers), 20 grams or 240-300 milligrams/kilogram of creatine has been taken by mouth daily for five days.

For enhanced athletic performance (runners), 0.35 grams/kilogram or 20-25 grams of creatine has been taken by mouth daily for 3-7 days.

For enhanced athletic performance (sports/general), 15-30 grams of creatine has been taken by mouth daily for five days to four weeks, as has 20 grams daily for five days followed by 5 grams daily for 10 weeks. A dose of 0.3 grams/kilogram of creatine has been taken by mouth daily for six days as a loading dose followed by 0.03 grams/kilogram daily for four weeks. Additionally, 20 grams of creatine has been taken by mouth daily on days 1-4, followed by 10 grams daily on days 5-6, and 5 grams daily on days 7-28.

For enhanced athletic performance (sprinters), 300 milligrams/kilogram or 10-35 grams of creatine has been taken daily for 2-7 days. Additionally, 15-20 grams of creatine has been taken daily for 5-7 days, followed by 2-10 grams daily for 9-21 days.

For enhanced athletic performance (power and spring performance), loading doses of 6-35 grams or 0.3 grams/kilogram of creatine have been taken daily for up to seven days, with maintenance doses of up to 10 grams or 0.03 grams/kilogram daily for up to seven weeks.

For enhanced athletic performance (swimming), 10-25 grams of creatine has been taken by mouth daily in single or divided doses for four to nine days. 0.3 grams/kilogram of creatine has been taken by mouth daily for five days followed by 2.25 grams daily. 20 grams of creatine has been taken by mouth daily for six days, followed by 10 grams daily for eight days.

For GAMT deficiency (lack of an enzyme for creatine production), 400-670 milligrams/kilogram has been taken daily by mouth. 4-8 grams of creatine has been taken daily by mouth for 25 months.

For heart health, 5 grams of creatine has been taken twice daily by mouth for three weeks. A dose of 7 grams of creatine has been taken three times daily by mouth for three days, then 21 grams once daily on the fourth day.

For heart attack, 2 grams of creatine has been injected into the blood, followed by 4 grams per hour injected into the blood for two hours. A dose of 4 grams has been injected into the blood, followed by 8 grams injected into the blood over two hours, and 8 grams per 24 hours injected into the blood for five days. Additionally, 18 grams of Neoton® has been injected into the blood for the first three days of a heart attack.

For Huntington's disease, 5-10 grams of creatine has been taken by mouth daily for up to one year.

For high cholesterol, 20-25 grams of creatine has been taken by mouth daily for five days, followed by 5-10 grams daily for 51 days.

For hyperornithinemia (high ornithine levels), 1.5 grams of creatine has been taken by mouth daily for one year.

For insulin potentiation, 5 grams of creatine has been taken by a tube into the stomach at three equally spaced intervals in one day. Additionally, 10 grams has been taken daily by mouth for greater than three months.

For ischemic heart disease, 400 milligrams of creatine has been injected into the muscle daily and 200 milligrams has been injected into the blood daily for 10 days.

For McArdle's disease (metabolism disorder), 150 milligrams/kilogram of creatine has been taken by mouth daily for five days, followed by 60 milligrams/kilogram daily for five weeks.

For memory, 5 grams of creatine taken by mouth once or four times daily has been taken from one to six weeks.

For muscle strength, 1 gram of creatine phosphate has been injected into the blood daily for 30 days.

For muscle wasting, 20 grams of creatine has been taken by mouth daily for five days, followed by a maintenance dose of 4.8 grams daily, for a total of 14 weeks. Additionally, 5 grams of creatine has been taken four times daily for seven days.

For muscular dystrophy, 10 grams of CreapureTM has been taken by mouth daily for eight weeks, 3 grams daily for three months, or 0.1 grams/kilogram daily for four months. A dosage of 3-20 grams of creatine daily or 0.06-0.15 grams/kilogram of creatine daily has been taken by mouth for one week to six months. 20 grams of creatine has been taken daily for one week, followed by 5 grams daily for an additional eight weeks.

For neuromuscular disorders, 10 grams of creatine has been taken by mouth daily for five to 14 days, followed by 4-5 grams daily for five to seven days. A dosage of 4-20 grams of creatine has been taken by mouth daily in 1-4 divided doses for five days to 4 weeks, as has 150 milligrams/kilogram daily for six weeks.

For orthostatic hypotension (low blood pressure upon standing), 20 grams of creatine has been taken by mouth daily for six days.

For osteoarthritis, 20 grams of creatine has been taken by mouth daily for one week, followed by 5 grams daily thereafter for 12 weeks.

For Parkinson's disease, 10 grams of creatine has been taken by mouth daily for 12 months.

For Rett syndrome (neurodevelopmental disorder), 200 milligrams/kilogram of creatine has been taken by mouth daily for six months.

For spinal cord injury, 10 grams of creatine has been taken by mouth twice daily for six days, then maintained with 5 grams daily. Additionally, 20 grams of creatine has been taken by mouth daily for seven days, followed by a 21-day washout period, then repeated for another seven days.

For surgical recovery (soft tissue), 10 grams of creatine has been taken daily by mouth for 10 days before surgery and 5 grams daily by mouth for 30 days after surgery.

Children (younger than 18 years)

For AGAT deficiency (lack of enzyme for creatine production), a child aged received up to 800 milligrams/kilogram of creatine by mouth daily and was followed for eight years.

For apnea (cessation of breathing), 200 milligrams/kilogram of creatine has been given by mouth daily for two weeks.

For GAMT deficiency (lack of an enzyme that produces creatine), the following doses have been given, 2 grams/kilogram of body weight by mouth, 4-8 grams by mouth daily in an infant for 25 months, and 400-670 milligrams/kilogram of body weight by mouth for up to two years. Dosing in children should be done under medical supervision because of potential adverse effects.

For muscular dystrophy, 5 grams of CreapureTM has been given by mouth daily for eight weeks.

For neuromuscular disorders, a dose of 0.1 gram/kilogram of creatine daily by mouth for one week has been used.

For Rett syndrome (neurodevelopmental disorder), children three years and older received 200 milligrams/kilogram of creatine by mouth daily for six months.

For spinal muscular atrophy, children aged 2-5 years were given 2 grams of creatine daily by mouth, and those aged 5-18 years were given 5 grams daily by mouth for six months.

For traumatic brain injury, 0.4 grams/kilogram of creatine oral suspension was taken by mouth daily for six months.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com