Interactions

Interactions with Drugs

CoQ10 may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). CoQ10 may also reduce the effectiveness of warfarin, which will increase risk of blood clot.

CoQ10 may affect blood sugar levels. Caution is advised when using medications that may also affect blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

CoQ10 may cause low blood pressure. Caution is advised in people taking drugs that affect blood pressure.

CoQ10 may also interact with acetylsalicylic acid, agents that may affect the immune system, agents that may affect the nervous system, agents that may enhance exercise performance, agents that may promote urination, agents that may treat asthma, agents that may treat mental illnesses, agents that may treat HIV, Alzheimer's agents, amiodarone, amitriptyline, anabolic androgenic steroids, angiotensin-converting enzyme inhibitors, anticancer agents, antidepressants, antifungal agents, anti-inflammatories, beta-blockers, cholesterol-lowering agents, clonidine, corticosteroids, cyclosporin A, dopamine agonists/antagonists, doxorubicin, eye agents, ezetimibe, fenofibrate, fertility agents, heart agents, heart rate-regulating agents, hormonal agents, hydralazine, immunoglobulins, iridium, lung agents, mercury, methyldopa, nicotine, nitroglycerin, orlistat, P-glycoprotein-regulated agents, skin agents, statins, steroids, thyroid hormones, timolol, and weight loss agents.

Interactions with Herbs and Dietary Supplements

CoQ10 may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases. CoQ10 may also reduce the effectiveness of warfarin, which will increase risk of blood clot.

CoQ10 may affect blood sugar levels. Caution is advised when using herbs or supplements that may also affect blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

CoQ10 may cause low blood pressure. Caution is advised in people taking herbs or supplements that affect blood pressure.

CoQ10 may also interact with alpha-lipoic acid, Alzheimer's agents, anticancer herbs and supplements, antidepressants, antifungal herbs and supplements, anti-inflammatories, antioxidants, antiviral herbs and supplements, beta-carotene, cholesterol-lowering herbs and supplements, dopamine agonists/antagonists, eye health herbs and supplements, fertility herbs and supplements, garlic, geranylgeraniol, gum arabic, heart health herbs and supplements, heart rate-regulating herbs and supplements, herbs and supplements that may affect the immune system, herbs and supplements that may affect the nervous system, herbs and supplements that may enhance exercise performance, herbs and supplements that may promote urination, herbs and supplements that may treat asthma, herbs and supplements that may treat mental disorders, hormonal herbs and supplements, L-carnitine, lung health herbs and supplements, MyoVive™, nutritional mitochondrial herbs and supplements, omega-3 fatty acids, Orthosiphon stamineus, P-glycoprotein-regulated herbs and supplements, red yeast rice (Monascus purpureus), salicylates, skin health herbs and supplements, thyroid herbs and supplements, vitamin A, vitamin B6, vitamin C, vitamin E, and weight loss herbs and supplements.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com